Broide Efrat, Sandbank Judith, Scapa Eitan, Kimchi Nimrod Alain, Shapiro Michael, Lerner Aaron
Institute of Gastroenterology, Assaf Harofeh Medical Center, Sackler School of Medicine, University of Tel-Aviv, Zerifin 70300, Israel.
Mediators Inflamm. 2007;2007:81838. doi: 10.1155/2007/81838.
Lymphocytic gastritis (LG) is associated with helicobacter pylori (Hp) and celiac disease (CD). We aimed to clarify the relationship between Hp infection and CD by defining a unique histopathology profile of LG in these two diseases. Forty patients who underwent upper endoscopy were divided into four groups: eight controls, ten active CD patients without Hp, twelve CD negative with Hp, and ten active CD with Hp infection. Antral samples were assessed by immunohistochemical staining for CD20, CD3, CD4, CD8, CD57, CNA42, and Ki67 for lymphoid aggregates, intraepithelial lymphocytes (IELs) number, density of lamina propria (LP) lymphocytes, and inflammatory glandular involvement. Only IELs positive for CD3 and CD8 were increased significantly in CD patients with or without Hp infection. Hp did not contribute to the number of CD8 IELs. In complicated cases with Hp and suspicious for CD, the number of CD8+ IELs hints toward a CD rather than Hp infection.
淋巴细胞性胃炎（LG）与幽门螺杆菌（Hp）及乳糜泻（CD）相关。我们旨在通过明确这两种疾病中LG独特的组织病理学特征来阐明Hp感染与CD之间的关系。40例行上消化道内镜检查的患者被分为四组：8例对照，10例无Hp感染的活动性CD患者，12例有Hp感染的CD阴性患者，以及10例有Hp感染的活动性CD患者。对胃窦样本进行免疫组织化学染色，检测CD20、CD3、CD4、CD8、CD57、CNA42和Ki67，以评估淋巴滤泡、上皮内淋巴细胞（IEL）数量、固有层（LP）淋巴细胞密度及炎性腺体受累情况。无论有无Hp感染，CD患者中仅CD3和CD8阳性的IEL显著增加。Hp对CD8阳性IEL的数量无影响。在合并Hp感染且怀疑为CD的复杂病例中，CD8 + IEL的数量提示为CD而非Hp感染。
