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憩室病在更年轻的年龄段中增多且有影响:一项关于10年趋势的流行病学研究。

Diverticular disease increases and effects younger ages: an epidemiological study of 10-year trends.

作者信息

Jeyarajah Santhini, Papagrigoriadis Savvas

机构信息

Colorectal Surgery, King's College Hospital, London, UK.

出版信息

Int J Colorectal Dis. 2008 Jun;23(6):619-27. doi: 10.1007/s00384-008-0446-8. Epub 2008 Feb 15.

Abstract

INTRODUCTION

Little data exists on epidemiological trends of diverticular disease (DD). This study of 2,979 admissions over 10 years aimed to examine the epidemiological trends of DD admissions and clinical outcomes.

METHODS

A retrospective analysis of all admissions with DD from 1995 to 2004 was performed. General population data for the area was obtained from the national Census and local primary care trust.

RESULTS

Annual admissions for DD increased from 71 to 263 (p = 0.000). There was a trend of decreasing mean age from 71.2 years in 1995 to 68.1 in 2004 (p = 0.06). Admissions younger than 50 years increased from eight in 1995 to 42 in 2003 (p = 0.005). The mean age and size of the catchment population remained stable in that time. More emergency admissions underwent surgery (14.4%, n = 54) than electives (6.1%, n = 66) and had longer lengths of stay (25.2 vs. 9.2 days; p = 0.000). More patients under 50 (19.6%, n = 21) had surgery compared with older ones (8.8%, n = 100; p = 0.000). Recurrent admissions increased from 18 to 72 per year (p = 0.000) but were not associated with poor clinical outcomes. There were 21 deaths overall. Deaths were more likely in emergencies (p = 0.000, OR = 56.42) and those aged over 80 (p = 0.000, OR = 2.87). Mortality was independent of co-morbidity and other demographic factors.

CONCLUSION

DD admissions increased, unexplained by an ageing population, increasingly affecting younger patients who are more likely to undergo surgery, particularly as emergencies. Emergency admissions are associated with longer stay and higher mortality. Recurrent admission cannot be used as guide to elective surgery. Efforts should be made to treat more DD electively.

摘要

引言

关于憩室病(DD)的流行病学趋势的数据很少。这项对10年间2979例住院病例的研究旨在探讨DD住院病例的流行病学趋势及临床结局。

方法

对1995年至2004年所有DD住院病例进行回顾性分析。该地区的一般人群数据来自全国人口普查和当地初级医疗信托机构。

结果

DD的年度住院病例数从71例增加到263例(p = 0.000)。平均年龄有下降趋势,从1995年的71.2岁降至2004年的68.1岁(p = 0.06)。50岁以下的住院病例数从1995年的8例增加到2003年的42例(p = 0.005)。在此期间,集水区人群的平均年龄和规模保持稳定。与择期手术患者(6.1%,n = 66)相比,更多急诊手术患者接受了手术(14.4%,n = 54),且住院时间更长(25.2天对9.2天;p = 0.000)。50岁以下的患者(19.6%,n = 21)接受手术的比例高于年龄较大的患者(8.8%,n = 100;p = 0.000)。复发性住院病例数从每年18例增加到72例(p = 0.000),但与不良临床结局无关。总共有21例死亡病例。急诊患者死亡的可能性更大(p = 0.000,OR = 56.42),80岁以上患者也是如此(p = 0.000,OR = 2.87)。死亡率与合并症和其他人口统计学因素无关。

结论

DD住院病例数增加,并非由人口老龄化所致,越来越多地影响年轻患者,这些患者更有可能接受手术,尤其是急诊手术。急诊住院与更长的住院时间和更高的死亡率相关。复发性住院不能作为择期手术的指导依据。应努力增加DD的择期治疗。

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