Nasoodi A, Lim L T, Al-Ani A, Quah S, Dinsmore W W
Genitourinary Department, Royal Victoria Hospital, Belfast BT12 6BA, UK.
Int J STD AIDS. 2008 Jan;19(1):4-11. doi: 10.1258/ijsa.2007.005666.
The early diagnosis and treatment of ocular disease to prevent morbidity and mortality of patients with human immunodeficiency virus (HIV) is of paramount importance. Since the advent of highly active antiretroviral therapy (HAART), the incidence of ocular complications of HIV has decreased and their manifestations and natural course are also modified. This has been observed in the face of emerging immune recovery, which per se has brought new difficulties in the process of diagnosing and management of the ocular disease. Conditions such as immune recovery uveitis could affect eyes with history of opportunistic disease with a potential to cause vision loss; with this regard, differentiation of the inflammatory process from infective causes is essential. The other sexually contracted diseases are also to be included in this complex picture because of their contribution to the clinical picture and also sharing common routes of transmission with HIV. There is very little doubt that visual deterioration would further deteriorate the already compromised quality of life of this group of patients. In this review, authors wish to provide evidence available in the medical literature around the visual health issues in HIV-infected patients and raise awareness towards the changing pattern of the ocular disease in the HAART era.
早期诊断和治疗眼部疾病以预防人类免疫缺陷病毒(HIV)患者的发病和死亡至关重要。自从高效抗逆转录病毒疗法(HAART)问世以来,HIV眼部并发症的发生率有所下降,其表现和自然病程也有所改变。这一现象出现在免疫恢复的背景下,而免疫恢复本身给眼部疾病的诊断和管理过程带来了新的困难。免疫恢复性葡萄膜炎等病症可能会影响有机会性疾病史的眼睛,有可能导致视力丧失;在这方面,区分炎症过程与感染原因至关重要。其他性传播疾病也应纳入这一复杂情况,因为它们对临床表现有影响,且与HIV有共同的传播途径。毫无疑问,视力下降会进一步恶化这群患者本已受损的生活质量。在这篇综述中,作者希望提供医学文献中有关HIV感染患者视觉健康问题的现有证据,并提高人们对HAART时代眼部疾病变化模式的认识。