Kublickiene Karolina, Luksha Leanid
Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Section for Obstetrics and Gynecology, Karolinska University hospital-Huddinge, Stockholm, Sweden.
Pharmacol Rep. 2008 Jan-Feb;60(1):49-60.
The understanding of the basis of gender differences in vascular function is of critical importance to establish gender targeted interventions in cardiovascular medicine. In this review we concentrate on the central role of the endothelium in respect to gender differences in cardiovascular physiology and pathophysiology. The role of estrogen and its receptors is introduced not only as key players in gender-related differences in incidence of cardiovascular abnormalities but also in endothelium-dependent maintenance of vascular tone through the release of endothelium-derived vasodilators and vasoconstrictors. An improved understanding of the distinct processes that confer vascular maintenance in women and men will help to develop new treatment alternatives and improve the use of existing drugs.
了解血管功能性别差异的基础对于在心血管医学中建立针对性别的干预措施至关重要。在本综述中，我们重点关注内皮细胞在心血管生理和病理生理性别差异方面的核心作用。雌激素及其受体的作用不仅被视为心血管异常发生率性别相关差异的关键因素，还被视为通过释放内皮源性血管舒张剂和血管收缩剂来维持内皮依赖性血管张力的关键因素。更好地理解赋予女性和男性血管维持的不同过程将有助于开发新的治疗选择并改善现有药物的使用。
