局灶节段性肾小球硬化症：最新进展
Focal segmental glomerulosclerosis: recent advances.
作者信息
Pollak Martin R
机构信息
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Curr Opin Nephrol Hypertens. 2008 Mar;17(2):138-42. doi: 10.1097/MNH.0b013e3282f5dbe4.
PURPOSE OF REVIEW
Focal segmental glomerulosclerosis is a significant and growing cause of chronic kidney disease and nephrotic syndrome in adults and children.
RECENT FINDINGS
The last year has seen continued progress in understanding podocyte biology, mechanisms of podocyte dysfunction, and its contribution to proteinuria and focal segmental glomerulosclerosis.
SUMMARY
A number of studies have helped to elucidate the mechanisms of slit-diaphragm-mediated signaling to the podocyte cytoskeleton. Advances in treatment continue to lag behind advances in understanding focal segmental glomerulosclerosis disease biology.
综述目的
局灶节段性肾小球硬化是成人和儿童慢性肾脏病及肾病综合征的一个重要且日益常见的病因。
最新发现
过去一年在理解足细胞生物学、足细胞功能障碍机制及其对蛋白尿和局灶节段性肾小球硬化的影响方面持续取得进展。
总结
多项研究有助于阐明裂孔隔膜介导的向足细胞细胞骨架信号传导的机制。在局灶节段性肾小球硬化疾病生物学理解方面取得进展的同时，治疗方面的进展仍较为滞后。
Zotero 插件