Latino M A, Caneparo A, Rosso C, De Maria D, De Intinis G, Intorcia P, Petrinco M
Department of Bacteriology, OIRM Sant'Anna Hospital, Turin, Italy.
Minerva Ginecol. 2008 Feb;60(1):29-37.
The aim of the study was to estimate the prevalence of Chlamydia trachomatis infection, risk factors and best predictors of infection in young sexually active women in north-west of Italy.
One thousand one hundred and eighty 18-24 years old women of family planning clinics and three STI Clinics over Turin city area underwent vaginal swabs to detect infection and completed a questionnaire. Logistic regression and multivariate analysis identified risk factors and a receiver operating characteristic (ROC) curve was used to assess the model accuracy.
Overall prevalence of infection was 10.4% 2.71 times higher (P<0.001) among women afferent to STI clinics than family planning clinics. Higher among women of Eastern European, Asian and South American ethnic origin (P=0.012) compared to Western European or African ethnic origin. Age at first intercourse (P=0.006), absence of a stable partner (P<0.001) partner with urogenital complaints (P<0.001), number of lifetime partners (P<0.001) number of partners in the last 6 months (P<0.001) history of occasional intercourse (P<0.001) and of IST (P<0.007) resulted associated with chlamydial infection. Multivariate analysis showed setting, partner with urogenital complaints and number of lifetime partners as best predictors of infection. ROC curve on variables from multivariate analysis showed an AUC of 0.732.
The study showed high rates of Chlamydial infection among sexually active women between 18-24 years in north-west area of Italy. Predictors of infection are related to sexual activity and to population sub-groups. Selective screening protocols should be supported by wider and more representative studies in order to increase knowledge and involve public opinion.
本研究旨在评估意大利西北部年轻性活跃女性沙眼衣原体感染的患病率、危险因素及感染的最佳预测因素。
来自都灵市地区计划生育诊所和三家性传播感染诊所的1180名18 - 24岁女性接受了阴道拭子检测以发现感染，并完成了一份问卷。逻辑回归和多变量分析确定了危险因素，并使用受试者工作特征（ROC）曲线评估模型准确性。
性传播感染诊所的女性感染总体患病率为10.4%，比计划生育诊所的女性高2.71倍（P<0.001）。东欧、亚洲和南美族裔女性的感染率高于西欧或非洲族裔女性（P = 0.012）。首次性交年龄（P = 0.006）、没有稳定伴侣（P<0.001）、伴侣有泌尿生殖系统疾病（P<0.001）、终身性伴侣数量（P<0.001）、过去6个月性伴侣数量（P<0.001）、偶尔性交史（P<0.001）和性传播感染史（P<0.007）均与衣原体感染有关。多变量分析显示，就诊机构、伴侣有泌尿生殖系统疾病和终身性伴侣数量是感染的最佳预测因素。多变量分析变量的ROC曲线显示曲线下面积（AUC）为0.732。
该研究表明，意大利西北部18 - 24岁性活跃女性衣原体感染率较高。感染的预测因素与性活动及人群亚组有关。应通过更广泛、更具代表性的研究来支持选择性筛查方案，以增加知识并争取公众支持。
