Siviková Katarína, Dianovský J, Piesová Elena, Holecková Beatá
Institute of Genetics, University of Veterinary Medicine, Komenského 73, 041 81 Kosice, Slovak Republic.
Acta Biol Hung. 2007 Dec;58(4):389-96. doi: 10.1556/ABiol.58.2007.4.6.
The effects of low doses of cyclohexanol exposure were studied in mouse bone marrow cells including chromosome aberrations (CA), micronucleus (MN) and sister chromatid exchanges (SCE) as biomarkers. Capillaries with a tested agent that was evaporated continuously were placed in an experimental chamber for six weeks. No clastogenic and/or aneugenic effect of CA and MN induction was observed. A significant elevation of induced damage was achieved in the SCE study (p < 0.001) that has confirmed the early exposure of cyclohexanol to mice.
以染色体畸变（CA）、微核（MN）和姐妹染色单体交换（SCE）作为生物标志物，研究了低剂量环己醇暴露对小鼠骨髓细胞的影响。将装有持续蒸发受试剂的毛细管置于实验箱中六周。未观察到CA和MN诱导的致断裂和/或致非整倍体效应。在SCE研究中诱导损伤显著升高（p < 0.001），这证实了小鼠早期暴露于环己醇。
