Falconer M, Molloy D, Ingerhaug J, Barry M
St James's Hospital, Dublin.
Ir Med J. 2007 Nov-Dec;100(10):631-2.
Adverse drug reactions account for approximately 5% of acute medical admissions. A 34-year-old male patient receiving antiretroviral therapy, methadone and flurazepam presented to the emergency room following collapse with associated loss of consciousness. Cardiac monitoring demonstrated marked Q-T prolongation followed by the cardiac arrhythmia, torsade de pointes. The patient made a full recovery following withdrawal of the antiretroviral therapy and a reduction in methadone dose. Methadone is a recognised cause of this potentially fatal cardiac arrhythmia which is more likely to occur when methadone metabolism is inhibited by drugs such as HIV tease inhibitors.
药物不良反应约占急性内科住院病例的5%。一名34岁男性患者正在接受抗逆转录病毒治疗、美沙酮和氟西泮治疗，在晕倒并伴有意识丧失后被送往急诊室。心脏监测显示Q-T间期显著延长，随后出现尖端扭转型室性心动过速这种心律失常。在停用抗逆转录病毒治疗并减少美沙酮剂量后，患者完全康复。美沙酮是这种潜在致命性心律失常的一个公认病因，当美沙酮代谢被诸如HIV蛋白酶抑制剂等药物抑制时，更有可能发生这种情况。
