Kashiwagi Satoshi, Tsukada Kosuke, Xu Lei, Miyazaki Junichi, Kozin Sergey V, Tyrrell James A, Sessa William C, Gerweck Leo E, Jain Rakesh K, Fukumura Dai
Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA.
Nat Med. 2008 Mar;14(3):255-7. doi: 10.1038/nm1730. Epub 2008 Feb 17.
Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
肿瘤血管正常化是一种正在兴起的改善细胞毒性疗法的策略。在此我们表明，通过神经元型一氧化氮合酶沉默或抑制消除肿瘤细胞中的一氧化氮生成，可在小鼠人胶质瘤异种移植瘤中建立血管周围一氧化氮梯度，并使肿瘤血管正常化，从而改善肿瘤氧合及对放射治疗的反应。建立血管周围一氧化氮梯度可能是使异常血管正常化的一种有效策略。
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