p53转录网络内调控多样性的机制。
Mechanisms of regulatory diversity within the p53 transcriptional network.
作者信息
Espinosa J M
机构信息
Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA.
出版信息
Oncogene. 2008 Jul 3;27(29):4013-23. doi: 10.1038/onc.2008.37. Epub 2008 Feb 18.
Abstract
p53 is arguably the most intensively studied protein to date, yet there is much that we ignore about its function as a transcription factor. The p53-dependent transcriptional program is remarkably flexible, as it varies with the nature of p53-activating stimuli, the cell type and the duration of the activation signal. This flexibility may allow cells to mount alternative responses to p53 activation, such as cell cycle arrest or apoptosis. Here, I organize the available data into two alternative models to explain how this regulatory diversity is achieved.
摘要
p53可以说是迄今为止研究最为深入的蛋白质，但作为一种转录因子，其功能仍有许多不为我们所知。p53依赖的转录程序非常灵活，因为它会随着p53激活刺激的性质、细胞类型以及激活信号的持续时间而变化。这种灵活性可能使细胞对p53激活产生不同的反应，如细胞周期停滞或凋亡。在此，我将现有数据整理成两种不同的模型，以解释这种调控多样性是如何实现的。
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