Liebermann Dan A, Hoffman Barbara, Vesely Diana
Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Cell Cycle. 2007 Jan 15;6(2):166-70. doi: 10.4161/cc.6.2.3789. Epub 2007 Jan 29.
The p53 tumor suppressor gene encodes for a transcription factor that plays a seminal role in the response of mammalian cells to physiological and environmental stress. p53 has been implicated as a major mediator of cell cycle arrest and/or apoptosis in the response of mammalian cells to stress stimuli. It appears that several determinants, including cell type, the presence or absence of survival factors in the external environment, the extent of DNA damage, the level of p53 and post-translational modifications, are involved in the choice between cell cycle arrest and apoptosis. Ongoing work on the biological functions of the p53 tumor suppressor in different cell types and under various physiological conditions will help to unravel the complex nature of molecular circuits that orchestrate the biological response to p53 activation.
p53肿瘤抑制基因编码一种转录因子，该转录因子在哺乳动物细胞对生理和环境应激的反应中起着至关重要的作用。p53被认为是哺乳动物细胞对应激刺激作出反应时细胞周期停滞和/或凋亡的主要调节因子。似乎包括细胞类型、外部环境中生存因子的存在与否、DNA损伤程度、p53水平和翻译后修饰在内的几个决定因素参与了细胞周期停滞和凋亡之间的选择。目前关于p53肿瘤抑制因子在不同细胞类型和各种生理条件下的生物学功能的研究，将有助于揭示协调对p53激活的生物学反应的分子回路的复杂本质。
