Scovassi A Ivana
Istituto di Genetica Molecolare CNR, Pavia, Italy.
Riv Biol. 2007 Sep-Dec;100(3):351-60.
Poly(ADP-ribosylation) is a post-translational modification of proteins with a multifunctional role in basic processes, such as DNA repair, transcription, cell proliferation and death. For decades, this reaction was studied by a small community of researchers, devoted to the identification of signals promoting the conversion of the coenzyme NAD into poly(ADP-ribose) and the further degradation of the polymers. The development of specific inhibitors and the discovery of a superfamily of poly(ADP-ribosylating) enzymes have recently conferred a higher importance to this process. The main features of poly(ADP-ribosylation) together with new research perspectives will be discussed.
多聚（ADP - 核糖基化）是一种蛋白质的翻译后修饰，在DNA修复、转录、细胞增殖和死亡等基本过程中发挥着多功能作用。几十年来，一小群致力于鉴定促进辅酶NAD转化为多聚（ADP - 核糖）以及聚合物进一步降解的信号的研究人员对这一反应进行了研究。特异性抑制剂的开发以及多聚（ADP - 核糖基化）酶超家族的发现，最近赋予了这一过程更高的重要性。本文将讨论多聚（ADP - 核糖基化）的主要特征以及新的研究前景。
