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Factors that may mediate the relationship between physical activity and the risk for developing knee osteoarthritis.可能介导身体活动与患膝骨关节炎风险之间关系的因素。
Arthritis Res Ther. 2008;10(1):203. doi: 10.1186/ar2343. Epub 2008 Feb 4.
2
A case-control study to investigate the relation between low and moderate levels of physical activity and osteoarthritis of the knee using data collected as part of the Allied Dunbar National Fitness Survey.一项病例对照研究，利用作为联合邓巴全国健身调查一部分收集的数据，调查低水平和中等水平的身体活动与膝关节骨关节炎之间的关系。
Ann Rheum Dis. 2001 Aug;60(8):756-64. doi: 10.1136/ard.60.8.756.
3
Association between MRI-defined osteoarthritis, pain, function and strength 3-10 years following knee joint injury in youth sport.膝关节损伤后 3-10 年青少年运动员的 MRI 定义的骨关节炎、疼痛、功能和力量之间的关系。
Br J Sports Med. 2018 Jul;52(14):934-939. doi: 10.1136/bjsports-2017-097576. Epub 2017 Oct 10.
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Health-related Outcomes after a Youth Sport-related Knee Injury.青少年运动相关膝关节损伤后的健康相关结局。
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History of acute knee injury and osteoarthritis of the knee: a prospective epidemiological assessment. The Clearwater Osteoarthritis Study.急性膝关节损伤病史与膝关节骨关节炎：一项前瞻性流行病学评估。清水骨关节炎研究。
Osteoarthritis Cartilage. 2002 Aug;10(8):611-6. doi: 10.1053/joca.2002.0795.
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Effect of Knee Extensor Strength on Incident Radiographic and Symptomatic Knee Osteoarthritis in Individuals With Meniscal Pathology: Data From the Multicenter Osteoarthritis Study.半月板病变个体中膝关节伸肌力量对膝关节X线片显示的和有症状的膝关节骨关节炎发病的影响：来自多中心骨关节炎研究的数据。
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Outcomes associated with early post-traumatic osteoarthritis and other negative health consequences 3-10 years following knee joint injury in youth sport.青少年运动中膝关节损伤后 3-10 年与早期创伤后骨关节炎及其他负面健康后果相关的结局。
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Obesity, physically demanding work and traumatic knee injury are major risk factors for knee osteoarthritis--a population-based study with a follow-up of 22 years.肥胖、体力劳动和膝关节创伤是膝骨关节炎的主要危险因素——一项基于人群的随访 22 年的研究。
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Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography.体重减轻对伴有膝关节骨关节炎的肥胖受试者的症状缓解是有效的，与高场 MRI 和放射摄影评估的关节损伤严重程度无关。
Osteoarthritis Cartilage. 2012 Jun;20(6):495-502. doi: 10.1016/j.joca.2012.02.639. Epub 2012 Mar 5.

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The Degradation of Synthetic Polymeric Scaffolds With Strut-like Architecture Influences the Mechanics-dependent Repair Process of an Osteochondral Defect .具有支柱状结构的合成聚合物支架的降解影响骨软骨缺损的力学依赖性修复过程。
Front Bioeng Biotechnol. 2022 Mar 10;10:846665. doi: 10.3389/fbioe.2022.846665. eCollection 2022.
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Evol Hum Behav. 2020 Sep;41(5):330-340. doi: 10.1016/j.evolhumbehav.2020.04.001. Epub 2020 Apr 14.
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Crosstalk between chitosan and cell signaling pathways.壳聚糖与细胞信号通路的相互作用。
Cell Mol Life Sci. 2019 Jul;76(14):2697-2718. doi: 10.1007/s00018-019-03107-3. Epub 2019 Apr 27.
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Chitosan oligosaccharides inhibit IL-1β-induced chondrocyte apoptosis via the P38 MAPK signaling pathway.壳寡糖通过P38丝裂原活化蛋白激酶信号通路抑制白细胞介素-1β诱导的软骨细胞凋亡。
Glycoconj J. 2016 Oct;33(5):735-44. doi: 10.1007/s10719-016-9667-1. Epub 2016 May 13.
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Dose-response relationship between sports activity and musculoskeletal pain in adolescents.青少年体育活动与肌肉骨骼疼痛之间的剂量反应关系。
Pain. 2016 Jun;157(6):1339-1345. doi: 10.1097/j.pain.0000000000000529.
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Self-Reported Knee Symptoms Assessed by KOOS Questionnaire in Downhill Runners (Skyrunners).通过KOOS问卷评估的下坡跑者（天空跑者）自我报告的膝盖症状
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10
Withaferin A-caused production of intracellular reactive oxygen species modulates apoptosis via PI3K/Akt and JNKinase in rabbit articular chondrocytes.印度楝素A诱导的细胞内活性氧生成通过PI3K/Akt和JNK激酶调节兔关节软骨细胞凋亡。
J Korean Med Sci. 2014 Aug;29(8):1042-53. doi: 10.3346/jkms.2014.29.8.1042. Epub 2014 Jul 30.

本文引用的文献

1
Obesity and knee osteoarthritis: new insights provided by body composition studies.
Obesity (Silver Spring). 2008 Feb;16(2):232-40. doi: 10.1038/oby.2007.30.
2
Effect of physical activity on articular knee joint structures in community-based adults.身体活动对社区成年人膝关节结构的影响。
Arthritis Rheum. 2007 Oct 15;57(7):1261-8. doi: 10.1002/art.22990.
3
The cross-sectional relationship between fortnightly exercise and knee cartilage properties in healthy adult women in midlife.中年健康成年女性中，每两周进行一次锻炼与膝关节软骨特性之间的横断面关系。
Menopause. 2007 Sep-Oct;14(5):830-4. doi: 10.1097/gme.0b013e31802f316b.
4
Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee.膝外翻和膝内翻对线与膝关节影像学骨关节炎的发生及进展之间的关联。
Arthritis Rheum. 2007 Apr;56(4):1204-11. doi: 10.1002/art.22515.
5
Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study.不同体重老年人的休闲体育活动对膝关节骨关节炎发展的影响：弗雷明汉姆研究
Arthritis Rheum. 2007 Feb 15;57(1):6-12. doi: 10.1002/art.22464.
6
Body composition and knee cartilage properties in healthy, community-based adults.健康社区成年人的身体成分与膝关节软骨特性
Ann Rheum Dis. 2007 Sep;66(9):1244-8. doi: 10.1136/ard.2006.064352. Epub 2007 Jan 29.
7
Osteophytes: relevance and biology.骨赘：相关性与生物学
Osteoarthritis Cartilage. 2007 Mar;15(3):237-44. doi: 10.1016/j.joca.2006.11.006. Epub 2007 Jan 3.
8
Effects of strength training on the incidence and progression of knee osteoarthritis.力量训练对膝关节骨关节炎发病率及进展的影响。
Arthritis Rheum. 2006 Oct 15;55(5):690-9. doi: 10.1002/art.22245.
9
The relationship between prospectively assessed body weight and physical activity and prevalence of radiological knee osteoarthritis in postmenopausal women.绝经后女性前瞻性评估的体重、身体活动与膝关节放射学骨关节炎患病率之间的关系。
J Rheumatol. 2006 Sep;33(9):1835-40. Epub 2006 Aug 1.
10
Static knee alignment and its association with radiographic knee osteoarthritis.静态膝关节对线及其与膝关节影像学骨关节炎的关联。
Osteoarthritis Cartilage. 2006 Sep;14(9):958-62. doi: 10.1016/j.joca.2006.04.014. Epub 2006 Jun 6.

可能介导身体活动与患膝骨关节炎风险之间关系的因素。

Factors that may mediate the relationship between physical activity and the risk for developing knee osteoarthritis.

作者信息

Urquhart Donna M, Soufan Cathy, Teichtahl Andrew J, Wluka Anita E, Hanna Fahad, Cicuttini Flavia M

机构信息

Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Commercial Road, Melbourne 3004, Australia.

出版信息

Arthritis Res Ther. 2008;10(1):203. doi: 10.1186/ar2343. Epub 2008 Feb 4.

DOI:10.1186/ar2343
PMID:18279536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2374461/
Abstract

Studies investigating the effect of physical activity on risk for developing osteoarthritis at weight-bearing joints have reported conflicting results. We examine evidence to suggest that this may be due to the existence of subgroups of individuals who differ in their response to physical activity, as well as methodological issues associated with the assessment of knee joint structure and physical activity. Recommendations for future studies of physical activity and the development of knee osteoarthritis are discussed.

摘要

关于体育活动对负重关节患骨关节炎风险影响的研究报告了相互矛盾的结果。我们研究证据表明，这可能是由于存在对体育活动反应不同的个体亚组，以及与膝关节结构评估和体育活动相关的方法学问题。文中还讨论了对未来体育活动与膝关节骨关节炎发展研究的建议。