Zhang Cheng-Ming, Yu Jin-Ling, Zhang Yan, Chen Li-Xia, Cao Huan-Jun, Wang Yu-Ying
Department of Anesthesiology, Affiliated Hospital of Weifang Medical College, Weifang 261042, Shandong, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Feb;20(2):108-10.
To study the effect of sufentanil on acute lung injury induced by hemorrhagic shock in rabbits.
Fifty-four healthy rabbits were randomly divided into three groups: control group,with only incision of trachea; model group, hemorrhagic shock was produced according to modified Wiggers' method; sufentanil group, intravenous injection of sufentanil at 0.02 microg x kg(-1) x h(-1) after hemorrhagic shock. To all the rabbits, intravenous Ringer lactate solution was given in an amount of 5 ml x kg(-1) x h(-1). Mean arterial pressure (MAP), heart rate (HR) and plasma tumor necrosis factor-alpha (TNF-alpha) were determined before shock, 1, 2, 3 and 4 hours after resuscitation. Malondialdehyde (MDA) and water content of lungs were measured 1, 2 and 4 hours after resuscitation.
At same time points, MAP and HR in sufentanil group and model group were lower than that in control group (P<0.05) but contents of TNF-alpha in serum, MDA in lung tissue and water content of lungs were elevated gradually. The degree of decrease or increase was less obvious in sufentanil than in model group (P<0.05 or P<0.01).
Hemorrhagic shock could increase arterial plasma TNF-alpha content with lung injury. Sufentanil could alleviate acute lung injury induced by hemorrhagic shock in rabbits.
研究舒芬太尼对兔失血性休克所致急性肺损伤的影响。
54只健康兔随机分为3组：对照组，仅行气管切开；模型组，按改良Wiggers法制作失血性休克模型；舒芬太尼组，失血性休克后静脉注射舒芬太尼0.02μg·kg⁻¹·h⁻¹。所有兔均以5ml·kg⁻¹·h⁻¹的速度静脉输注乳酸林格液。分别于休克前、复苏后1、2、3及4小时测定平均动脉压（MAP）、心率（HR）及血浆肿瘤坏死因子-α（TNF-α）。复苏后1、2及4小时测定肺组织丙二醛（MDA）含量及肺含水量。
在相同时间点，舒芬太尼组和模型组的MAP和HR均低于对照组（P<0.05），但血清TNF-α含量、肺组织MDA含量及肺含水量均逐渐升高。舒芬太尼组上述指标的升降幅度均小于模型组（P<0.05或P<0.01）。
失血性休克可使动脉血浆TNF-α含量升高并导致肺损伤。舒芬太尼可减轻兔失血性休克所致的急性肺损伤。
