Iversen Kasper Karmark, Teisner Ane Sogaard, Teisner Borge, Kliem Anette, Bay Morten, Kirk Vibeke, Nielsen Henrik, Boesgaard Soren, Grande Peer, Clemmensen Peter
The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Clin Biochem. 2008 May;41(7-8):548-53. doi: 10.1016/j.clinbiochem.2008.01.012. Epub 2008 Jan 31.
PAPP-A is a promising new marker in coronary heart disease. It is important to investigate its specificity in order to establish its clinical utility as a marker of coronary heart disease.
PAPP-A was measured within 24 h following hospital admission in 1448 consecutive patients admitted with diagnoses other than acute coronary syndromes.
PAPP-A was detectable (> or = 4.0 mIU/L) in 278 (19.2%) patients, among whom the mean level was 6.3 mIU/L (95% C.I., 6.1-6.5 mIU/L). The 95 and 99 percentiles for PAPP-A were 7.3 and 9.4 mIU/L, respectively. There was no difference in the mean PAPP-A of different diagnoses (p=0.33). None of the specific diagnoses known to influence established coronary markers appeared to influence the level of circulating PAPP-A.
PAPP-A is low in patients without known coronary heart disease. PAPP-A levels seem to be a potentially highly specific marker for heart disease.
妊娠相关血浆蛋白A（PAPP-A）是冠心病一种很有前景的新型标志物。为确立其作为冠心病标志物的临床应用价值，研究其特异性很重要。
对1448例因非急性冠脉综合征以外的疾病入院的连续患者在入院后24小时内检测PAPP-A。
278例（19.2%）患者可检测到PAPP-A（≥4.0 mIU/L），其中平均水平为6.3 mIU/L（95%可信区间，6.1 - 6.5 mIU/L）。PAPP-A的第95和第99百分位数分别为7.3和9.4 mIU/L。不同诊断的患者PAPP-A平均水平无差异（p = 0.33）。已知影响既定冠脉标志物的任何特定诊断似乎均未影响循环PAPP-A水平。
在无已知冠心病的患者中PAPP-A水平较低。PAPP-A水平似乎是心脏病一种潜在的高特异性标志物。
