Liu Xue-Ting, Wang Zhen-Zhong, Xiao Wei, Zhao Hui-Wu, Hu Jie, Yu Biao
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, PR China.
Phytochemistry. 2008 Apr;69(6):1411-8. doi: 10.1016/j.phytochem.2007.12.014. Epub 2008 Feb 14.
Cholestane glycosides, dioseptemlosides A (1) and B (2), together with six spirostane glycosides, dioseptemlosides C-H (3-8), were isolated from the rhizomes of Dioscorea septemloba. Their structures were established on the basis of physical data, spectroscopic analysis (HRESIMS, 1D and 2D NMR), and chemical methods. Spirostane aglcones containing hydroxyl group at C-7, as found in compounds 4-7, were reported in the family Dioscoreaceae for the first time. These compounds did not show considerable inhibitory anti-tumor activities at a concentration of 10 microM.
从绵萆薢的根茎中分离出了胆甾烷糖苷、二 Septemloside A（1）和 B（2），以及六种螺旋甾烷糖苷，即二 Septemloside C-H（3-8）。它们的结构是根据物理数据、光谱分析（高分辨电喷雾电离质谱、一维和二维核磁共振）以及化学方法确定的。在化合物 4-7 中发现的在 C-7 位含有羟基的螺旋甾烷苷元，首次在薯蓣科中被报道。这些化合物在 10 μM 的浓度下没有表现出显著的抑制抗肿瘤活性。
