Prevrhal Sven, Shepherd John A, Faulkner Kenneth G, Gaither Ken W, Black Dennis M, Lang Thomas F
Department of Radiology, UCSF, San Francisco, CA 94107, USA.
J Clin Densitom. 2008 Apr-Jun;11(2):232-6. doi: 10.1016/j.jocd.2007.12.001. Epub 2008 Feb 15.
Hip structural analysis (HSA) estimates geometrical and mechanical properties from hip dual-energy X-ray absorptiometry (DXA) images and is widely used in osteoporosis trials. This study compares HSA to volumetric quantitative computed tomography (QCT) measurements in the same population. A total of 121 women (mean age 58 yr, mean body mass index 27 kg/m2) participated. Each woman received a volumetric QCT scan and DXA scan of the left hip. QCT scans were analyzed with in-house software that directly computed geometric and mechanical parameters at the neck and trochanteric regions. DXA HSA was performed with an implementation by GE/Lunar. Pair-wise linear regression of HSA variables was conducted by method to site matched QCT variables for bone density, cross-sectional area, and cross-sectional moment of inertia (CSMI) of the femur neck. HSA correlated well with QCT (r2=0.67 for neck bone mineral density [BMD] and 0.5 for CSMI) and standard DXA at the neck (r2=0.82 for BMD). HSA and volumetric QCT compared favorably, which supports the validity of a projective technique such as DXA to derive geometrical properties of the proximal hip.
髋部结构分析（HSA）可从髋部双能X线吸收测定法（DXA）图像估算几何和力学特性，在骨质疏松症试验中被广泛应用。本研究在同一人群中将HSA与容积定量计算机断层扫描（QCT）测量结果进行比较。共有121名女性（平均年龄58岁，平均体重指数27kg/m²）参与。每位女性均接受了左髋部的容积QCT扫描和DXA扫描。QCT扫描采用内部软件进行分析，该软件可直接计算颈部和转子区的几何和力学参数。DXA HSA采用GE/Lunar的实施方案进行。通过方法对股骨颈骨密度、横截面积和截面惯性矩（CSMI）的HSA变量与匹配部位的QCT变量进行成对线性回归。HSA与QCT相关性良好（股骨颈骨矿物质密度[BMD]的r² = 0.67，CSMI的r² = 0.5），与颈部标准DXA相关性良好（BMD的r² = 0.82）。HSA与容积QCT相比表现良好，这支持了如DXA这样的投影技术用于推导近端髋部几何特性的有效性。
