Skeletal Health, Hologic, Inc., Bedford, MA, USA.
Osteoporos Int. 2012 Feb;23(2):543-51. doi: 10.1007/s00198-011-1578-1. Epub 2011 Mar 11.
In a population of elderly women, bone cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), section modulus (Z), femoral neck axis length (FNAL), and width measured with hip structure analysis (HSA) on dual-energy x-ray absorptiometry (DXA) images in the femoral neck and trochanteric regions are highly correlated to quantitative computed tomography (QCT) measurements.
HSA is a method of obtaining measurements of proximal femur structure using 2D DXA technology. This study was designed to examine the correlations between HSA measurements and 3D QCT.
Forty-one women (mean age, 82.8 ± 2.5 years) were measured using DXA and a 64-slice CT scanner (1 mm slice thickness, 0.29 mm in plane resolution). HSA parameters were calculated at the narrow neck (NN) and trochanteric (IT) regions on the DXA image. These regions were then translated to anatomically equivalent regions on the QCT dataset by co-registering the DXA image and QCT dataset using four DXA images acquired at different angles.
At the NN and IT regions, high linear correlations were measured between HSA and QCT for CSA r = 0.95 and 0.93, CSMI r = 0.94 and 0.93, and Z r = 0.93 and 0.89, respectively. All correlations were highly significant (p < 0.001), but there were differences in slope and offset between the two techniques, at least in part due to differences in calibration between the two techniques. FNAL and width of the bone at the NN and IT regions, physical measurements independent of the calibration, were highly correlated (r = 0.90-0.95, p < 0.001) and had slopes close to 1.0 (range, 0.978 to 1.003).
CSA, CSMI, Z, FNAL, and width measured by HSA correlate highly to high-resolution QCT.
在老年女性人群中，骨横截面积（CSA）、横截面惯性矩（CSMI）、截面模数（Z）、股骨颈轴长（FNAL）以及通过双能 X 射线吸收法（DXA）在股骨颈和转子区域的髋结构分析（HSA）测量的宽度与定量计算机断层扫描（QCT）测量值高度相关。
HSA 是一种使用 2D DXA 技术获取股骨近端结构测量值的方法。本研究旨在检验 HSA 测量值与 3D QCT 的相关性。
41 名女性（平均年龄，82.8±2.5 岁）使用 DXA 和 64 层 CT 扫描仪（1 毫米切片厚度，0.29 毫米平面分辨率）进行测量。在 DXA 图像上计算窄颈（NN）和转子（IT）区域的 HSA 参数。然后，通过使用在不同角度获取的四张 DXA 图像对 DXA 图像和 QCT 数据集进行配准，将这些区域转换到 QCT 数据集上的解剖学等效区域。
在 NN 和 IT 区域，HSA 与 QCT 之间的 CSA 测量值高度相关（r=0.95 和 0.93）、CSMI（r=0.94 和 0.93）和 Z（r=0.93 和 0.89）。所有相关性均高度显著（p<0.001），但两种技术之间存在斜率和截距的差异，至少部分原因是两种技术之间的校准差异。NN 和 IT 区域的 FNAL 和骨宽，是与校准无关的物理测量值，高度相关（r=0.90-0.95，p<0.001），斜率接近 1.0（范围为 0.978 至 1.003）。
HSA 测量的 CSA、CSMI、Z、FNAL 和宽度与高分辨率 QCT 高度相关。
