从鳗鱼心室中分离出的一种新型利钠肽。

A novel natriuretic peptide isolated from eel cardiac ventricles.

作者信息

Takei Y, Takahashi A, Watanabe T X, Nakajima K, Sakakibara S

机构信息

Department of Physiology, Kitasato University School of Medicine, Kanagawa, Japan.

出版信息

FEBS Lett. 1991 May 6;282(2):317-20. doi: 10.1016/0014-5793(91)80504-v.

DOI:10.1016/0014-5793(91)80504-v

PMID:1828035

Abstract

A new natriuretic peptide, which exhibits the entire spectrum of actions known to be characteristic of atrial and brain natriuretic peptides (ANP and BNP), was isolated from eel cardiac ventricles and has been named ventricular natriuretic peptide (VNP). The primary structure of eel VNP is characterized by its uniquely long C-terminal 'tail' that extends from the second half-cystine. Thus, eel VNP appears to be a novel natriuretic peptide of a type not found in mammals. With respect to natriuretic (rat) and vasodepressor (rat and eel) activities, eel VNP is much more potent than human ANP in eels and almost equipotent in rats. Strong tachyphylaxis is observed for the vasodepressor effect in both rats and eels, whereas it is not observed for the natriuretic effect in rats.

摘要

从鳗鱼心室中分离出一种新的利钠肽，它具有已知的心房利钠肽和脑利钠肽（ANP和BNP）所特有的全部作用谱，并被命名为心室利钠肽（VNP）。鳗鱼VNP的一级结构的特征在于其独特的长C末端“尾巴”，该尾巴从第二个半胱氨酸延伸。因此，鳗鱼VNP似乎是一种在哺乳动物中未发现的新型利钠肽。就利钠（大鼠）和血管降压（大鼠和鳗鱼）活性而言，鳗鱼VNP在鳗鱼中比人ANP更有效，在大鼠中几乎等效。在大鼠和鳗鱼中均观察到血管降压作用有强烈的快速耐受性，而在大鼠中未观察到利钠作用有快速耐受性。