GABAa和GABAc受体对青蛙视网膜电图中b波和d波强度-反应函数的介导影响。
GABAa and GABAc receptor mediated influences on the intensity-response functions of the b- and d-wave in the frog ERG.
作者信息
Kupenova P, Popova E, Vitanova L
机构信息
Department of Physiology, Medical University, 1 G, Sofiiski Str, 1431 Sofia, Bulgaria.
出版信息
Vision Res. 2008 Mar;48(7):882-92. doi: 10.1016/j.visres.2008.01.003. Epub 2008 Feb 15.
We assessed the contribution of GABAa and GABAc receptors to GABAergic effects on b- and d-wave in frog ERG in a wide range of light stimulation conditions. The amplitude of both b- and d-wave was increased during GABAa receptor blockade by bicuculline as well as during additional GABAc receptor blockade by picrotoxin. The effects of GABAa receptor blockade were more pronounced in light adaptation conditions. They strongly depended on stimulus intensity and showed considerable ON/OFF-response asymmetry. The effects of GABAc receptor blockade were more pronounced in dark adaptation conditions. They didn't vary much with stimulus intensity and showed little ON/OFF-response asymmetry.
我们在广泛的光刺激条件下，评估了GABAa和GABAc受体对蛙视网膜电图中GABA能对b波和d波作用的贡献。在荷包牡丹碱阻断GABAa受体期间以及在印防己毒素额外阻断GABAc受体期间，b波和d波的振幅均增加。GABAa受体阻断的作用在明适应条件下更为明显。它们强烈依赖于刺激强度，并表现出明显的开/关反应不对称性。GABAc受体阻断的作用在暗适应条件下更为明显。它们随刺激强度变化不大，且开/关反应不对称性较小。
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