Patel Sarsvatkumar, Kaushal Aditya Mohan, Bansal Arvind Kumar
Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research, SAS. Nagar, India.
Eur J Pharm Biopharm. 2008 Jun;69(2):743-9. doi: 10.1016/j.ejpb.2008.01.005. Epub 2008 Jan 16.
The effect of roller compaction pressure on the bulk compaction of roller compacted ibuprofen was investigated using instrumented rotary tablet press. Three different roller pressures were utilized to prepare granules and Heckel analysis, Walker analysis, compressibility, and tabletability were performed to derive densification, deformation, course of volume reduction and bonding phenomenon of different pressure roller compacted granules. Nominal single granule fracture strength was obtained by micro tensile testing. Heckel analysis indicated that granules prepared using lower pressure during roller compaction showed lower yield strength. The reduction in tabletability was observed for higher pressure roller compacted granules. The reduction in tabletability supports the results of granule size enlargement theory. Apart from the granule size enlargement theory, the available fines and relative fragmentation during compaction is responsible for higher bonding strength and provide larger areas for true particle contact at constant porosity for lower pressure roller compacted granules. Overall bulk compaction parameters indicated that granules prepared by lower roller compaction pressure were advantageous in terms of tabletability and densification. Overall results suggested that densification during roller compaction affects the particle level properties of specific surface area, nominal fracture strength, and compaction behavior.
使用装有仪器的旋转压片机研究了滚压压力对滚压布洛芬松密度的影响。采用三种不同的滚压压力制备颗粒，并进行赫克尔分析、沃克分析、可压性和压片性测定，以得出不同压力滚压颗粒的致密化、变形、体积减小过程和粘结现象。通过微拉伸试验获得标称单颗粒断裂强度。赫克尔分析表明，滚压过程中使用较低压力制备的颗粒表现出较低的屈服强度。对于较高压力滚压的颗粒，观察到压片性降低。压片性的降低支持了颗粒尺寸增大理论的结果。除颗粒尺寸增大理论外，压实过程中可用细粉和相对破碎导致较低压力滚压颗粒在恒定孔隙率下具有更高的粘结强度，并为真实颗粒接触提供更大面积。总体松密度参数表明，较低滚压压力制备的颗粒在压片性和致密化方面具有优势。总体结果表明，滚压过程中的致密化会影响比表面积、标称断裂强度和压实行为等颗粒级性能。
