de Bree Remco, Moll Annette C, Imhof Saskia M, Buter Jan, Leemans C René
Department of Otolaryngology/Head and Neck Surgery, Vrije Universiteit Medical Center, P.O. Box 7057, De Boelelaan 1117, 1081 Amsterdam, The Netherlands.
Oral Oncol. 2008 Oct;44(10):982-5. doi: 10.1016/j.oraloncology.2007.12.005. Epub 2008 Feb 15.
Hereditary retinoblastoma patients are at an increased risk for subsequent primary tumors after successful treatment for their initial cancer. Two mechanisms may be responsible for this increased incidence of second malignancies: genetic susceptibility (RB1 gene alterations) and induction by radiation that is frequently used as treatment for retinoblastoma. Because of the high cure rates obtained in the treatment of retinoblastoma, the risk of subsequent primary tumors is substantial, especially in the radiation field. We present four retinoblastoma survivors who developed multiple subsequent primary tumors. Two retinoblastoma survivors developed one and the other two patients two subsequent primary tumors. Despite extensive treatments two patients died of their second primary tumor in the head and neck region. The head and neck surgeon has an increasingly important role in the diagnosis and management of subsequent primary tumors in retinoblastoma survivors.
遗传性视网膜母细胞瘤患者在成功治疗其初始癌症后，发生后续原发性肿瘤的风险增加。这种继发性恶性肿瘤发病率增加可能有两种机制：遗传易感性（RB1基因改变）和常用于视网膜母细胞瘤治疗的辐射诱导。由于视网膜母细胞瘤治疗取得了较高的治愈率，后续原发性肿瘤的风险很大，尤其是在放疗区域。我们报告了四名发生了多个后续原发性肿瘤的视网膜母细胞瘤幸存者。两名视网膜母细胞瘤幸存者各发生了1个后续原发性肿瘤，另外两名患者各发生了2个后续原发性肿瘤。尽管接受了广泛治疗，仍有两名患者死于头颈部区域的第二原发性肿瘤。头颈部外科医生在视网膜母细胞瘤幸存者后续原发性肿瘤的诊断和管理中发挥着越来越重要的作用。
