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Applications for ROCK kinase inhibition.
Curr Opin Cell Biol. 2008 Apr;20(2):242-8. doi: 10.1016/j.ceb.2008.01.002. Epub 2008 Feb 20.
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Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential.
J Med Chem. 2016 Mar 24;59(6):2269-300. doi: 10.1021/acs.jmedchem.5b00683. Epub 2015 Oct 30.
3
The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling.
J Mol Med (Berl). 2017 Feb;95(2):155-165. doi: 10.1007/s00109-016-1469-1. Epub 2016 Aug 30.
5
Development of Rho-kinase inhibitors for cardiovascular medicine.
Trends Pharmacol Sci. 2007 Jun;28(6):296-302. doi: 10.1016/j.tips.2007.04.006. Epub 2007 May 7.
7
Evaluation of clinical efficacy of fasudil for the treatment of pulmonary arterial hypertension.
Recent Pat Cardiovasc Drug Discov. 2012 Aug;7(2):100-4. doi: 10.2174/157489012801227238.
8
Current status of rho-associated kinases (ROCKs) in coronary atherosclerosis and vasospasm.
Cardiovasc Hematol Agents Med Chem. 2009 Oct;7(4):322-30. doi: 10.2174/187152509789541891.
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FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity.
Biosci Rep. 2015 Jul 29;35(5):e00247. doi: 10.1042/BSR20150032.

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Endothelial calcium firing mediates the extravasation of metastatic tumor cells.
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Tension-induced organelle stress: an emerging target in fibrosis.
Trends Pharmacol Sci. 2025 Feb;46(2):117-131. doi: 10.1016/j.tips.2024.12.006. Epub 2025 Jan 15.
3
Endothelial Rho kinase controls blood vessel integrity and angiogenesis.
bioRxiv. 2024 Nov 19:2024.11.19.624343. doi: 10.1101/2024.11.19.624343.
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Glaucoma: Current and New Therapeutic Approaches.
Biomedicines. 2024 Sep 3;12(9):2000. doi: 10.3390/biomedicines12092000.
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The Role of Rho Kinase Inhibitors in Corneal Diseases.
Drug Des Devel Ther. 2024 Jan 19;18:97-108. doi: 10.2147/DDDT.S435522. eCollection 2024.
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ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease.
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本文引用的文献

1
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
Nat Cell Biol. 2008 Feb;10(2):127-37. doi: 10.1038/ncb1675. Epub 2008 Jan 20.
2
The selectivity of protein kinase inhibitors: a further update.
Biochem J. 2007 Dec 15;408(3):297-315. doi: 10.1042/BJ20070797.
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A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.
Surg Neurol. 2007 Aug;68(2):126-31; discussion 131-2. doi: 10.1016/j.surneu.2006.10.037. Epub 2007 Jun 21.
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A ROCK inhibitor permits survival of dissociated human embryonic stem cells.
Nat Biotechnol. 2007 Jun;25(6):681-6. doi: 10.1038/nbt1310. Epub 2007 May 27.
7
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.
EMBO J. 2007 May 2;26(9):2262-73. doi: 10.1038/sj.emboj.7601683. Epub 2007 Apr 19.
8
Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.
J Cardiovasc Pharmacol. 2007 Mar;49(3):117-21. doi: 10.1097/FJC.0b013e31802ef532.
9
LIM kinases: function, regulation and association with human disease.
J Mol Med (Berl). 2007 Jun;85(6):555-68. doi: 10.1007/s00109-007-0165-6. Epub 2007 Feb 10.
10
Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.
J Am Coll Cardiol. 2007 Feb 13;49(6):698-705. doi: 10.1016/j.jacc.2006.06.082. Epub 2007 Jan 26.

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