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青光眼:当前及新的治疗方法

Glaucoma: Current and New Therapeutic Approaches.

作者信息

Lee Hsin-Pei, Tsung Ta-Hsin, Tsai Yu-Chien, Chen Yi-Hao, Lu Da-Wen

机构信息

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Department of Ophthalmology, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan.

出版信息

Biomedicines. 2024 Sep 3;12(9):2000. doi: 10.3390/biomedicines12092000.

DOI:10.3390/biomedicines12092000
PMID:39335514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11429057/
Abstract

Glaucoma is identified by the loss of retinal ganglion cells (RGCs). The primary approach to managing glaucoma is to control intraocular pressure (IOP). Lately, there has been an increasing focus on neuroprotective therapies for glaucoma because of the limited effectiveness of standard methods in reducing IOP and preventing ongoing vision deterioration in certain glaucoma patients. Various drug-based techniques with neuroprotective properties have demonstrated the ability to decrease the mortality of retinal ganglion cells. This study will analyze the currently recommended drug-based techniques for neuroprotection in the prospective treatment of glaucoma.

摘要

青光眼是由视网膜神经节细胞(RGCs)的丧失所确定的。治疗青光眼的主要方法是控制眼压(IOP)。最近,由于标准方法在降低眼压和预防某些青光眼患者持续视力恶化方面效果有限,对青光眼神经保护疗法的关注日益增加。各种具有神经保护特性的基于药物的技术已证明有能力降低视网膜神经节细胞的死亡率。本研究将分析目前推荐的用于青光眼前瞻性治疗的基于药物的神经保护技术。

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本文引用的文献

1
Optic Nerve Neuroprotection in Glaucoma: A Narrative Review.青光眼的视神经神经保护:一篇叙述性综述
J Clin Med. 2024 Apr 11;13(8):2214. doi: 10.3390/jcm13082214.
2
Travoprost Intracameral Implant for Open-Angle Glaucoma or Ocular Hypertension: 12-Month Results of a Randomized, Double-Masked Trial.曲伏前列素前房内植入治疗开角型青光眼或高眼压症:一项随机双盲试验的12个月结果
Ophthalmol Ther. 2024 Apr;13(4):995-1014. doi: 10.1007/s40123-024-00898-y. Epub 2024 Feb 12.
3
Real-World Study of the Effectiveness and Safety of Intracameral Bimatoprost Implant in a Clinical Setting in the United States.美国临床环境中前房注射比马前列素植入物有效性和安全性的真实世界研究。
Clin Ophthalmol. 2024 Jan 19;18:187-199. doi: 10.2147/OPTH.S445005. eCollection 2024.
4
Overview of Recent Advances in Nano-Based Ocular Drug Delivery.基于纳米的眼部药物输送的最新进展概述。
Int J Mol Sci. 2023 Oct 19;24(20):15352. doi: 10.3390/ijms242015352.
5
Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy.Rho激酶抑制剂作为青光眼治疗的新兴靶点。
Ophthalmol Ther. 2023 Dec;12(6):2943-2957. doi: 10.1007/s40123-023-00820-y. Epub 2023 Oct 14.
6
Efficacy of citicoline as a supplement in glaucoma patients: A systematic review.胞磷胆碱作为青光眼患者补充剂的疗效:系统评价。
PLoS One. 2023 Sep 28;18(9):e0291836. doi: 10.1371/journal.pone.0291836. eCollection 2023.
7
Nanotechnology-based ocular drug delivery systems: recent advances and future prospects.基于纳米技术的眼部药物传递系统:最新进展与未来展望。
J Nanobiotechnology. 2023 Jul 22;21(1):232. doi: 10.1186/s12951-023-01992-2.
8
Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering.青光眼的神经保护:眼压降低以外的机制。
Mol Aspects Med. 2023 Aug;92:101193. doi: 10.1016/j.mam.2023.101193. Epub 2023 Jun 16.
9
Neuroprotective effect of the calcium channel blocker nilvadipine on retinal ganglion cell death in a mouse ocular hypertension model.钙通道阻滞剂尼伐地平对小鼠高眼压模型视网膜神经节细胞死亡的神经保护作用。
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Erythropoietin in Glaucoma: From Mechanism to Therapy.红细胞生成素在青光眼:从机制到治疗。
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