Zhu Waner, Zhang Rong, Hu Changchun, Umegaki Hiroyuki
Department of Medical Psychology, Zhejiang University Graduate School of Medicine, Hangzhou, China.
Neuro Endocrinol Lett. 2008 Feb;29(1):159-62.
In our previous study, a lesion in the entorhinal cortex was found to significantly attenuate the elevation of adrenocorticotropic hormone (ACTH) in plasma during immobilization stress. The aim of the present study was to investigate whether the entorhinal cortex exerts a modulatory effect on circadian ACTH and corticosterone release.
Ibotenic acid (15 microg/microl) was stereotaxically bilaterally injected into the entorhinal cortex of rats. Two weeks after the injections, ACTH and corticosterone levels in plasma were measured at 0800 h, 1300 h and 1800 h.
Compared with sham-operated control rats, rats with entorhinal cortex lesions produced by ibotenic acid showed either significantly elevated plasma ACTH or plasma corticosterone levels at 0800 h, but no difference at 1300 h or 1800 h.
The results of the present study indicate that the entorhinal cortex plays a certain role in the regulation by the central nervous system of the circadian rhythm of the hypothalamic-pituitary-adrenal (HPA) axis.
在我们之前的研究中，发现内嗅皮质的损伤会显著减弱固定应激期间血浆中促肾上腺皮质激素（ACTH）的升高。本研究的目的是调查内嗅皮质是否对昼夜节律性促肾上腺皮质激素和皮质酮释放发挥调节作用。
将异博定（15微克/微升）双侧立体定向注射到大鼠的内嗅皮质。注射两周后，在08:00、13:00和18:00测量血浆中促肾上腺皮质激素和皮质酮水平。
与假手术对照大鼠相比，用异博定造成内嗅皮质损伤的大鼠在08:00时血浆促肾上腺皮质激素或血浆皮质酮水平显著升高，但在13:00或18:00时无差异。
本研究结果表明，内嗅皮质在中枢神经系统对下丘脑-垂体-肾上腺（HPA）轴昼夜节律的调节中起一定作用。
