甲状腺功能减退女性的循环抵抗素水平较低，但与甲状腺激素浓度无关。

Circulating resistin levels are lower in hypothyroid women but independent from thyroid hormones concentrations.

作者信息

Owecki Maciej, El Ali Ziad, Waśko Ryszard, Nikisch Elzbieta, Sowiński Jerzy

机构信息

Department of Endocrinology and Metabolism, University of Medical Sciences in Poznan, Poznan, Poland.

出版信息

Neuro Endocrinol Lett. 2008 Feb;29(1):131-6.

PMID:18283268

Abstract

OBJECTIVES

Although resistin is involved in metabolism, its role in humans is unclear. Since thyroid status influences metabolism, and since only few studies have evaluated the associations between resistin and thyroid status with inconclusive results, we investigated serum serum resistin levels and their correlations with TSH, FT4 and FT3 in hypothyroid and euthyroid women.

DESIGN AND METHODS

Study group consisted of 22 women with a history of total thyroidectomy and radioiodine ablation performed for thyroid cancer. Controls were 22 healthy euthyroid women matched for age and BMI. After six-weeks of thyroxine withdrawal, subjects were admitted to the Department of Endocrinology of the Poznan University of Medical Sciences to perform this study.

RESULTS

Serum resistin concentrations were lower in hypothyroid patients, 12.40 +/- 5.197 vs. 18.01 +/- 7.31, p=0.0065. In hypothyroid subjects, correlations were as follows: r of -0.2636 and p of 0.248, r of 0.0336 and p of 0.885, and r of 0.3080 and P of 0.174 for resistin and FT4, resistin and FT3, and resistin and TSH, respectively. In controls: r of 0.0311 and p of 0.8908, r of -0.0986 and p of 0.6625, and r of 0.1605 and p of 0.4754 for resistin and FT4, resistin and FT3, and resistin and TSH, respectively.

CONCLUSIONS

Short-term profound hypothyroidism decreased resistin levels. However, no significant correlations between the levels of circulating resistin and thyroid hormones and TSH were shown.

摘要

目的

尽管抵抗素参与新陈代谢，但其在人类中的作用尚不清楚。由于甲状腺状态会影响新陈代谢，且仅有少数研究评估了抵抗素与甲状腺状态之间的关联，结果尚无定论，因此我们研究了甲状腺功能减退和甲状腺功能正常女性的血清抵抗素水平及其与促甲状腺激素（TSH）、游离甲状腺素（FT4）和游离三碘甲状腺原氨酸（FT3）的相关性。

设计与方法

研究组由22名因甲状腺癌接受全甲状腺切除术和放射性碘消融术的女性组成。对照组为22名年龄和体重指数相匹配的健康甲状腺功能正常女性。在停用甲状腺素六周后，受试者被收入波兹南医科大学内分泌科进行本研究。

结果

甲状腺功能减退患者的血清抵抗素浓度较低，分别为12.40±5.197和18.01±7.31，p = 0.0065。在甲状腺功能减退受试者中，抵抗素与FT4、抵抗素与FT3、抵抗素与TSH的相关性分别为：r为 -0.2636，p为0.248；r为0.0336，p为0.885；r为0.3080，P为0.174。在对照组中，抵抗素与FT4、抵抗素与FT3、抵抗素与TSH的相关性分别为：r为0.0311，p为0.8908；r为 -0.0986，p为0.6625；r为0.1605，p为0.4754。