Ziora Katarzyna T, Oswiecimska Joanna M, Swietochowska Elzbieta, Ostrowska Zofia, Stojewska Małgorzata, Gorczyca Piotr, Rojewska Katarzyna, Ziora-Jakutowicz Karolina, Szczepanska Maria, Ziora Dariusz
Department of Paediatrics, Silesian Medical University, Zabrze, Poland.
Neuro Endocrinol Lett. 2011;32(5):697-703.
Thyroid, adrenal glands and gonadal hormones play a role in maintaining metabolic homeostasis of the body via the receptors located in the adipose tissue. The correlations between serum resistin (RES) and function of other hormonal axes in patients with AN have not been established, yet. Therefore, the aim of this study is: 1) assessment of concentrations of thyroid hormones (FT4, TSH), adrenal hormones (ACTH, cortisol), sex hormones (LH, FSH, estradiol, testosterone); 2) establishing their relationship with BMI and 3) analysis of correlations between examined hormones and RES serum concentrations in adolescent female patients with AN.
Serum RES (ELISA) and fT4, TSH, ACTH, LH, FSH, estradiol and testosterone (ECLIA) concentrations have been assayed in 195 adolescent girls: 87 with restrictive AN, 17 with not otherwise specified eating disorders (NOS), 30 with simple obesity (OB) and 61 healthy (H) subjects.
Mean serum FT4, LH and estradiol concentrations were significantly lower (p=0.015; p<0.0001; p<0.0001, respectively) in AN than in OB group, and cortisol increased (p<0.001) compared to OB and H subjects. In all examined subjects BMI correlated positively (p<0.0001) with LH (r=0.61) and estradiol (r=0.30), and negatively with cortisol (r=-0.35; p=0.008). Also the significant positive relationship between serum RES and FT4 (r=0.34), LH (r=0.57) as well as estradiol (r=0.28) was observed, whereas serum cortisol correlated negatively with RES (r=-0.40).
Changes in resistin serum concentrations in eating disorders may be involved in the altered regulation of hypothalamic-pituitary-adrenal, thyroid and gonadal axes.
甲状腺、肾上腺和性腺激素通过位于脂肪组织中的受体，在维持机体代谢稳态方面发挥作用。目前，神经性厌食症（AN）患者血清抵抗素（RES）与其他激素轴功能之间的相关性尚未明确。因此，本研究旨在：1）评估甲状腺激素（游离甲状腺素[FT4]、促甲状腺激素[TSH]）、肾上腺激素（促肾上腺皮质激素[ACTH]、皮质醇）、性激素（促黄体生成素[LH]、促卵泡生成素[FSH]、雌二醇、睾酮）的浓度；2）确定它们与体重指数（BMI）的关系；3）分析青春期女性AN患者中所检测激素与RES血清浓度之间的相关性。
对195名青春期女孩进行了血清RES（酶联免疫吸附测定[ELISA]）以及FT4、TSH、ACTH、LH、FSH、雌二醇和睾酮（电化学发光免疫分析[ECLIA]）浓度的检测，其中包括87名患有限制性AN的女孩、17名患有未特定指明的进食障碍（NOS）的女孩、30名单纯性肥胖（OB）的女孩以及61名健康（H）受试者。
与OB组相比，AN组的血清FT4、LH和雌二醇平均浓度显著降低（分别为p = 0.015；p < 0.0001；p < 0.0001），与OB组和H组受试者相比，皮质醇升高（p < 0.001）。在所有检测受试者中，BMI与LH（r = 0.61）和雌二醇（r = 0.30）呈正相关（p < 0.0001），与皮质醇呈负相关（r = -0.35；p = 0.008）。还观察到血清RES与FT4（r = 0.34）、LH（r = 0.57）以及雌二醇（r = 0.28）之间存在显著正相关，而血清皮质醇与RES呈负相关（r = -0.40）。
进食障碍中抵抗素血清浓度的变化可能参与了下丘脑 - 垂体 - 肾上腺、甲状腺和性腺轴调节的改变。
