Li Zhichuan, Xie Zijian
Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, Mail Stop 1008, 3000 Arlington Avenue, Toledo, OH 43614-2598, USA.
Pflugers Arch. 2009 Jan;457(3):635-44. doi: 10.1007/s00424-008-0470-0. Epub 2008 Feb 19.
The Na/K-ATPase was discovered by Skou in 1957. Since then, the efforts of numerous investigators have led to the following conclusions: (a) This enzyme is indeed the molecular machine for the ATP-dependent and -coupled transport of Na(+) and K(+) across the plasma membrane of a living cell in which such a process (sodium pump) is detected. (b) The Na/K-ATPase is also an important signal transducer that not only interacts and regulates protein kinases, but also functions as a scaffold, capable of bringing the affector and effectors together to form functional signalosomes. This minireview discusses the interaction between the Na/K-ATPase and Src to illustrate how a P-type ATPase can act as a receptor, converting a ligand-binding signal to the activation of protein kinase cascades and the generation of second messengers.
钠钾ATP酶于1957年由斯科发现。从那时起，众多研究人员的努力得出了以下结论：(a) 这种酶确实是负责钠（Na⁺）和钾（K⁺）在活细胞膜上进行ATP依赖且偶联转运的分子机器，在该细胞膜中可检测到这种过程（钠泵）。(b) 钠钾ATP酶也是一种重要的信号转导分子，它不仅与蛋白激酶相互作用并对其进行调节，还作为一种支架发挥作用，能够将效应物和受动器聚集在一起形成功能性信号小体。本综述讨论了钠钾ATP酶与Src之间的相互作用，以说明一种P型ATP酶如何作为受体发挥作用，将配体结合信号转化为蛋白激酶级联反应的激活以及第二信使的产生。
