Noske Aurelia, Schwabe Michael, Pahl Stefan, Fallenberg Eva, Richter-Ehrenstein Christiane, Dietel Manfred, Kristiansen Glen
Institute of Pathology, Charité University Hospital Berlin, Campus Mitte, Charitéplatz 1, Berlin 10117, Germany.
Virchows Arch. 2008 May;452(5):575-9. doi: 10.1007/s00428-008-0588-7.
Metaplastic carcinoma of the breast is a heterogeneous neoplasia, generally composed of both epithelial and mesenchymal components. We report an unusual case of mammary metaplastic carcinoma in a 51-year-old female patient. Needle core biopsy from the tumour mass showed malignant epithelial and sarcomatous features. The resection specimen revealed a multi-directional tumour differentiation consisting predominantly of: firstly, a poorly differentiated basaloid epithelial cell type, consistent with an adenoid cystic carcinoma; secondly, areas of a spindle cell carcinoma; and, thirdly, areas with a melanocytic differentiation. This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma.
乳腺化生性癌是一种异质性肿瘤，通常由上皮和间充质成分组成。我们报告了一例51岁女性患者的罕见乳腺化生性癌病例。对肿瘤肿块进行的粗针穿刺活检显示出恶性上皮和肉瘤样特征。切除标本显示出多向性肿瘤分化，主要包括：首先，一种低分化的基底样上皮细胞类型，与腺样囊性癌一致；其次，梭形细胞癌区域；第三，具有黑素细胞分化的区域。这是关于乳腺化生性癌表现为腺样囊性癌和黑色素瘤混合的首例报告。
