Soylu Ahmet, Tokaç Mehmet, Cora Tülin, Düzenli Mehmet Akif, Acar Hasan
Department of Cardiology, Meram Medical School of Selcuk University, S.U. Meram Tip Fakültesi Kardiyoloji AD, Konya, Turkey.
J Thromb Thrombolysis. 2009 Apr;27(3):259-66. doi: 10.1007/s11239-008-0204-3. Epub 2008 Feb 19.
The -5T/C polymorphism in the Kozak sequence of glycoprotein Ibalpha, a component of the platelet glycoprotein Ib-IX-V receptor complex, is associated with an increase in this receptor density on the surface of the platelet. This study was designed to investigate the effect of platelet glycoprotein Ibalpha Kozak polymorphism on the clinical presentation of the patients with acute pulmonary embolism.
Forty-two patients with pulmonary embolism were genotyped for Kozak polymorphism of the glycoprotein Ibalpha by polymerase chain reaction/restriction fragment length polymorphism.
Carriers of the -5T/C polymorphism of glycoprotein Ibalpha were significantly over-represented in the patient group with clinically massive or submassive pulmonary embolism (odds ratio 5.5, 95% confidence interval 1.4 to 22.2, P = 0.023). Also the association between this polymorphism and massive or submassive pulmonary embolism still existed even after being adjusted for conventional risk factors.
The -5T/C polymorphism in the Kozak sequence of glycoprotein Ibalpha may present as a risk factor for clinical manifestation of pulmonary embolism in which clot burden plays an important role.
血小板糖蛋白Ib-IX-V受体复合物的组成成分糖蛋白Ibalpha的科扎克序列中的-5T/C多态性，与血小板表面该受体密度增加有关。本研究旨在调查血小板糖蛋白Ibalpha科扎克多态性对急性肺栓塞患者临床表现的影响。
采用聚合酶链反应/限制性片段长度多态性方法，对42例肺栓塞患者进行糖蛋白Ibalpha科扎克多态性基因分型。
在临床诊断为大面积或次大面积肺栓塞的患者组中，糖蛋白Ibalpha的-5T/C多态性携带者显著过多（优势比5.5，95%置信区间1.4至22.2，P = 0.023）。即使在对传统危险因素进行校正后，该多态性与大面积或次大面积肺栓塞之间的关联仍然存在。
糖蛋白Ibalpha科扎克序列中的-5T/C多态性可能是肺栓塞临床表现的一个危险因素，其中血栓负荷起重要作用。
