传递沉默：小干扰RNA疗法开发的进展

Delivering silence: advancements in developing siRNA therapeutics.

作者信息

Novobrantseva Tatiana I, Akinc Akin, Borodovsky Anna, de Fougerolles Antonin

机构信息

Alnylam Pharmaceuticals Inc, 300 Third Street, Cambridge, MA 02142, USA.

出版信息

Curr Opin Drug Discov Devel. 2008 Mar;11(2):217-24.

DOI:

PMID:18283609

Abstract

The number of small interfering RNA (siRNA)-based therapeutics that are in or nearing human clinical trials is rapidly expanding. This review summarizes recent in vivo data obtained from studies on siRNA therapeutics and gives an overview of the key in vivo delivery technologies in use today. A section is also devoted to currently ongoing clinical trials employing siRNA drugs.

摘要

进入或即将进入人体临床试验的基于小干扰RNA（siRNA）的疗法数量正在迅速增加。本综述总结了近期从siRNA疗法研究中获得的体内数据，并概述了当今使用的关键体内递送技术。其中一节还专门介绍了目前正在进行的使用siRNA药物的临床试验。