Shegokar R, Al Shaal L, Mishra P R
Institute of Pharmacy, Department of Pharmaceutics, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Germany.
Pharmazie. 2011 May;66(5):313-8.
Gene silencing by RNA interference is a rapidly growing therapeutic area for managing diseases. Despite research advances in this direction, the poor cellular uptake of synthetic small interfering RNAs is a major impediment to their clinical applications. Polymer and lipid-based systems are attractive carrier systems for delivery of siRNA and provide options for desirable engineering of carrier particles. In this review, there is a detailed discussion of RNAi delivery systems and recent advances in the field.
通过RNA干扰实现的基因沉默是疾病治疗领域中一个迅速发展的方向。尽管在这方面的研究取得了进展，但合成小干扰RNA的细胞摄取率低是其临床应用的主要障碍。基于聚合物和脂质的系统是用于递送小干扰RNA的有吸引力的载体系统，并为载体颗粒的理想工程设计提供了选择。在这篇综述中，详细讨论了RNA干扰递送系统以及该领域的最新进展。
