[CD8+CD57+淋巴细胞对细胞介导细胞毒性的抑制作用：抑制因子的特性]
[Inhibitor effect of CD8+CD57+ lymphocytes on cell-mediated cytotoxicity: characterization of suppressor factor].
作者信息
Autran B, Sadat-Sowti B, Debre P
机构信息
Laboratoire d'Immunologie cellulaire et tissulaire, U.A.-C.N.R.S. n. 186, Paris.
出版信息
C R Acad Sci III. 1991;312(5):197-202.
We report a new suppressor function of CD8+CD57+ lymphocytes from HIV-seropositive patients or allotransplanted recipients, on the cytolytic activity of allospecific CTL, NK and LAK cells. This inhibitory effect is mediated by a non-antigen specific soluble factor distinct from PGE2, TGF beta and TNF alpha beta. A preliminary biochemical characterization indicates that the CD8+CD57+ inhibitory activity 1. is heat and trypsin resistant, 2. specifically binds to Concanavalin A suggesting its glycosylation, 3. is mediated by a 20-30 kD molecule.
我们报告了来自HIV血清阳性患者或同种异体移植受者的CD8+CD57+淋巴细胞对同种异体特异性CTL、NK和LAK细胞的细胞溶解活性具有一种新的抑制功能。这种抑制作用由一种不同于PGE2、TGFβ和TNFαβ的非抗原特异性可溶性因子介导。初步生化特性表明，CD8+CD57+抑制活性：1. 耐热且耐胰蛋白酶；2. 特异性结合伴刀豆球蛋白A，提示其具有糖基化；3. 由一个20 - 30 kD的分子介导。
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