Bazzett T J, Eaton R C, Thompson J T, Markowski V P, Lumley L A, Hull E M
Department of Psychology, SUNY, Buffalo 14260.
Life Sci. 1991;48(24):2309-15. doi: 10.1016/0024-3205(91)90267-f.
This study investigated the effects on genital reflexes of unilateral MPOA injections of 0.1, 1, 3, and 10 micrograms of the D2 agonist quinelorane (LY-163502), and of 3 micrograms quinelorane administered together with 3 micrograms of the D1 antagonist SCH-23390. In addition, the effects of an MPOA injection of 10 micrograms apomorphine were tested. All but the lowest dose of quinelorane significantly decreased the latency to the first reflex. The 3 and 10 micrograms doses of quinelorane, and the combination of quinelorane and SCH-23390, decreased the total number of reflexes. In addition, 10 micrograms quinelorane increased the number of seminal emissions. 10 micrograms apomorphine, like 10 micrograms quinelorane, decreased the latency to the first reflex and increased the number of seminal emissions, but did not decrease the numbers of erections or penile movements. The ratio of D1/D2 activity may influence the number of erections displayed during ex copula testing.
本研究调查了单侧内侧视前区（MPOA）注射0.1、1、3和10微克D2激动剂喹那佐啉（LY - 163502），以及3微克喹那佐啉与3微克D1拮抗剂SCH - 23390联合注射对生殖反射的影响。此外，还测试了MPOA注射10微克阿扑吗啡的效果。除最低剂量的喹那佐啉外，其他剂量均显著缩短了首次反射的潜伏期。3微克和10微克剂量的喹那佐啉，以及喹那佐啉与SCH - 23390的组合，均减少了反射的总数。此外，10微克喹那佐啉增加了射精次数。10微克阿扑吗啡与10微克喹那佐啉一样，缩短了首次反射的潜伏期并增加了射精次数，但未减少勃起或阴茎运动的次数。D1/D2活性的比率可能会影响交配后测试中显示的勃起次数。
