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DNA adducts of allyl compounds, enals and unsaturated ketones. Significance for mutagenicity and carcinogenicity.烯丙基化合物、烯醛和不饱和酮的DNA加合物。对致突变性和致癌性的意义。
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Toxicity, DNA binding, and cell proliferation in male F344 rats following short-term gavage exposures to trans-2-hexenal.雄性F344大鼠短期经口灌胃接触反式-2-己烯醛后的毒性、DNA结合及细胞增殖情况
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DNA damage caused by lipid peroxidation products.由脂质过氧化产物引起的DNA损伤。
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Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation.由ω-3和ω-6多不饱和脂肪酸形成反式-4-羟基-2-壬烯醛及其他烯醛衍生的环状DNA加合物及其在DNA修复和人类p53基因突变中的作用。
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Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells.主要脂质过氧化产物反式-4-羟基-2-壬烯醛的突变谱和遗传毒性在核苷酸切除修复功能正常和缺陷的人类细胞中诱导DNA加合物形成。
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Chem Res Toxicol. 2008 Nov;21(11):2097-105. doi: 10.1021/tx800169a.

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本文引用的文献

1
Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide.通过谷胱甘肽和谷胱甘肽二硫化物的稳定同位素稀释液相色谱/质谱分析来测定细胞氧化还原状态。
Rapid Commun Mass Spectrom. 2008;22(4):432-40. doi: 10.1002/rcm.3380.
2
Targeted chiral lipidomics analysis by liquid chromatography electron capture atmospheric pressure chemical ionization mass spectrometry (LC-ECAPCI/MS).通过液相色谱-电子捕获大气压化学电离质谱法（LC-ECAPCI/MS）进行靶向手性脂质组学分析。
Methods Enzymol. 2007;433:159-74. doi: 10.1016/S0076-6879(07)33009-7.
3
Metabolism and elimination of the endogenous DNA adduct, 3-(2-deoxy-beta-D-erythropentofuranosyl)-pyrimido[1,2-alpha]purine-10(3H)-one, in the rat.大鼠体内内源性DNA加合物3-(2-脱氧-β-D-赤藓戊呋喃糖基)-嘧啶并[1,2-α]嘌呤-10(3H)-酮的代谢与消除
J Biol Chem. 2007 Dec 14;282(50):36257-64. doi: 10.1074/jbc.M706814200. Epub 2007 Oct 19.
4
Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells.大鼠肠上皮细胞中环氧合酶-2介导的花生四烯酸代谢生成15-氧代二十碳四烯酸。
Chem Res Toxicol. 2007 Nov;20(11):1665-75. doi: 10.1021/tx700130p. Epub 2007 Oct 2.
5
A novel 4-oxo-2(E)-nonenal-derived endogenous thiadiazabicyclo glutathione adduct formed during cellular oxidative stress.一种在细胞氧化应激过程中形成的新型4-氧代-2（E）-壬烯醛衍生的内源性噻二氮杂双环谷胱甘肽加合物。
Chem Res Toxicol. 2007 Jul;20(7):1008-18. doi: 10.1021/tx700001t. Epub 2007 Jun 6.
6
Endogenous glutathione adducts.内源性谷胱甘肽加合物
Curr Drug Metab. 2006 Dec;7(8):853-72. doi: 10.2174/138920006779010601.
7
Translesion DNA Synthesis across the heptanone--etheno-2'-deoxycytidine adduct in cells.细胞中跨庚酮 - 乙烯基 - 2'-脱氧胞苷加合物的跨损伤DNA合成
Chem Res Toxicol. 2006 Aug;19(8):1074-9. doi: 10.1021/tx0600503.
8
Endogenous lipid hydroperoxide-mediated DNA-adduct formation in min mice.内源性脂质过氧化氢介导的Min小鼠DNA加合物形成
J Biol Chem. 2006 Apr 14;281(15):10127-33. doi: 10.1074/jbc.M600178200. Epub 2006 Jan 31.
9
Induction of endothelial cell apoptosis by lipid hydroperoxide-derived bifunctional electrophiles.脂质氢过氧化物衍生的双功能亲电试剂诱导内皮细胞凋亡
Free Radic Biol Med. 2005 Nov 1;39(9):1162-76. doi: 10.1016/j.freeradbiomed.2005.06.008.
10
Cyclooxygenase-2-mediated DNA damage.环氧化酶-2介导的DNA损伤。
J Biol Chem. 2005 Aug 5;280(31):28337-46. doi: 10.1074/jbc.M504178200. Epub 2005 Jun 17.

DNA adducts with lipid peroxidation products.

作者信息

Blair Ian A

机构信息

Center for Cancer Pharmacology and Excellence in Environmental Toxicology and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.

出版信息

J Biol Chem. 2008 Jun 6;283(23):15545-9. doi: 10.1074/jbc.R700051200. Epub 2008 Feb 19.

DOI:10.1074/jbc.R700051200
PMID:18285329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2414303/
Abstract
摘要