Gupta Sandeep, Rosenberg Mark E
Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Am J Nephrol. 2008;28(4):607-13. doi: 10.1159/000117311. Epub 2008 Feb 19.
Adult stem cells exist in many organs and play a critical role in normal cell turnover and the response to injury. The existence of adult stem cells in the mammalian kidney remains controversial. Kidney stem cells have been isolated and characterized by many groups, often with discrepant results. This article will review the current state of knowledge regarding adult kidney stem cells and discuss future directions for kidney stem cell research.
成体干细胞存在于许多器官中,在正常细胞更新和损伤反应中发挥关键作用。哺乳动物肾脏中是否存在成体干细胞仍存在争议。许多研究小组已分离并鉴定出肾脏干细胞,但其结果常常存在差异。本文将综述目前关于成体肾脏干细胞的知识现状,并讨论肾脏干细胞研究的未来方向。