目前对炎症性肠病发病机制中真菌微生物群的认识。
Current understanding of fungal microflora in inflammatory bowel disease pathogenesis.
作者信息
Underhill David, Braun Jonathan
机构信息
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
出版信息
Inflamm Bowel Dis. 2008 Aug;14(8):1147-53. doi: 10.1002/ibd.20402.
Abstract
Inflammatory bowel diseases are a current and growing public health problem, with a prevalence that appears to be increasing in most countries and cultures. While most research into the triggering phenomenon has focused on the interaction between commensal bacteria and inflammatory bowel disease, enteric fungi may also be important in determining disease susceptibility. Herein we review what is known about enteric fungi and the mechanisms by which they and their dysregulation might be involved in triggering inflammatory diseases of the bowel.
摘要
炎症性肠病是当前一个日益严重的公共卫生问题，在大多数国家和文化中，其患病率似乎都在上升。虽然大多数关于触发该现象的研究都集中在共生细菌与炎症性肠病之间的相互作用上，但肠道真菌在决定疾病易感性方面可能也很重要。在此，我们综述了关于肠道真菌及其失调可能参与引发肠道炎症性疾病的机制的已知信息。
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