Oei-Lim L B, Vermeulen-Cranch D M, Bouvy-Berends E C
Department of Anaesthesiology, Academic Medical Centre, Amsterdam.
Br Dent J. 1991 May 11;170(9):340-2. doi: 10.1038/sj.bdj.4807526.
Propofol by continuous intravenous infusion was used as an alternative to nitrous oxide/oxygen for conscious sedation in 19 patients undergoing out-patient dental treatment. Patients were either extremely anxious or mentally and/or physically handicapped. Propofol was administered by a syringe pump at an initial rate of 3 mg/kg/hour. During the procedure the infusion rate was adjusted to attain and maintain the desired level of conscious sedation. The mean time from starting the propofol infusion until reaching the required level of sedation was 11.5 (SD 3.5) minutes. The mean infusion rate was 3.6 (SD 0.65) mg/kg/hour. The average duration of the dental procedure was 55.9 (SD 18.8) minutes. Sedation was satisfactory in all but two patients. There were no side-effects. Recovery was rapid after stopping the infusion. It is concluded that propofol is an acceptable alternative to nitrous oxide/oxygen for conscious sedation in the dental surgery.
19例接受门诊牙科治疗的患者，采用丙泊酚持续静脉输注作为氧化亚氮/氧气用于清醒镇静的替代方法。患者要么极度焦虑，要么存在精神和/或身体残疾。丙泊酚通过注射泵以初始速率3mg/kg/小时给药。在手术过程中，调整输注速率以达到并维持所需的清醒镇静水平。从开始输注丙泊酚到达到所需镇静水平的平均时间为11.5（标准差3.5）分钟。平均输注速率为3.6（标准差0.65）mg/kg/小时。牙科手术的平均持续时间为55.9（标准差18.8）分钟。除两名患者外，所有患者的镇静效果均令人满意。未出现副作用。停止输注后恢复迅速。结论是，在牙科手术中，丙泊酚是氧化亚氮/氧气用于清醒镇静的可接受替代药物。
