欧洲分子生物学实验室核苷酸序列与基因组综述数据库。

The EMBL Nucleotide Sequence and Genome Reviews Databases.

作者信息

Sterk Peter, Kulikova Tamara, Kersey Paul, Apweiler Rolf

机构信息

EMBL-Outstation The European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, Cambridge, UK.

出版信息

Methods Mol Biol. 2007;406:1-21. doi: 10.1007/978-1-59745-535-0_1.

DOI:10.1007/978-1-59745-535-0_1

PMID:18287686

Abstract

Nucleotide and protein sequence databases are major resources for biological and medical research. This chapter introduces the European Molecular Biology Laboratory (EMBL) Nucleotide Sequence Database, a comprehensive primary data archive for nucleic acid sequences, and Genome Reviews, a secondary database that provides an up-to-date, standardized and comprehensively annotated view of the genomic sequence of selected organisms with completely deciphered genomes. Focusing on plant nucleotide sequences, we demonstrate how these data are accessed, how sequence similarity searches are performed and how we can obtain a wealth of additional information relating to genome sequences using Integr8.

摘要

核苷酸和蛋白质序列数据库是生物学和医学研究的主要资源。本章介绍欧洲分子生物学实验室（EMBL）核苷酸序列数据库，这是一个全面的核酸序列原始数据存档库，以及基因组综述，这是一个二级数据库，它提供了对已完全破译基因组的选定生物的基因组序列的最新、标准化和全面注释的视图。以植物核苷酸序列为重点，我们展示了如何访问这些数据、如何进行序列相似性搜索，以及如何使用Integr8获得与基因组序列相关的大量其他信息。