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科威特儿童中的无菌性脑膜炎

Aseptic meningitis among children in Kuwait.

作者信息

Husain Entesar H, Bahbahani Esmaeel, Al-Shawaf Faisal, El-Nabi Mamdooh Hasab, Shafiq Majdi Hilmi, Al-Ateeqi Nahid, Talib Atef Abo

机构信息

Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat, Kuwait.

出版信息

Med Princ Pract. 2008;17(2):122-5. doi: 10.1159/000112965. Epub 2008 Feb 19.

Abstract

OBJECTIVE

To describe the epidemiology, clinical features, and the morbidity caused by aseptic meningitis in children in Kuwait.

SUBJECTS AND METHOD

A multicenter retrospective study of previously healthy children hospitalized with a diagnosis of aseptic meningitis in the period 2001-2003 was carried out.

RESULTS

There were 172 children with the diagnosis of meningitis based on changes in the cerebrospinal fluid. Aseptic meningitis was diagnosed in 86 (50%) of the cases; their mean age was 3.2 +/- 3.8 years. There were two peaks of cases, one during the months of May and June and the other in November/December. Older children (>or=5 years) presented more frequently with signs and symptoms suggestive of meningeal irritation than younger children (<5 years) (p <or= 0.01). The median duration of hospitalization was 7 days. The majority (n = 56, 65%) received a 7- to 10-day course of antibiotics despite negative cerebrospinal fluid cultures. Six (7%) hospitalized children had complications: 3 had convulsions, 2 were ventilated, and 1 had motor palsy. Intensive care unit admission was necessary in 3. All the children were discharged home without sequelae. There were no mortalities in the study group.

CONCLUSIONS

Aseptic meningitis among children in Kuwait is a major cause of morbidity and requires prolonged hospitalization. The complication rate is low and there were no sequelae or mortality among the studied cohort.

摘要

目的

描述科威特儿童无菌性脑膜炎的流行病学、临床特征及发病率。

对象与方法

对2001 - 2003年期间因诊断为无菌性脑膜炎而住院的既往健康儿童进行多中心回顾性研究。

结果

根据脑脊液变化诊断为脑膜炎的儿童有172例。其中86例(50%)诊断为无菌性脑膜炎;他们的平均年龄为3.2±3.8岁。病例有两个高峰,一个在5月和6月,另一个在11月/ 12月。年龄较大的儿童(≥5岁)比年龄较小的儿童(<5岁)更常出现提示脑膜刺激的体征和症状(p≤0.01)。住院时间中位数为7天。尽管脑脊液培养阴性,但大多数(n = 56,65%)接受了7至10天的抗生素治疗疗程。6例(7%)住院儿童出现并发症:3例惊厥,2例需要通气,1例有运动性麻痹。3例需要入住重症监护病房。所有儿童均出院回家,无后遗症。研究组无死亡病例。

结论

科威特儿童无菌性脑膜炎是发病的主要原因,需要长时间住院治疗。并发症发生率低,研究队列中无后遗症或死亡病例。

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