Meissner K, Weyer U, Kowalzick L, Altenhoff J
Department of Dermatology, University of Hamburg School of Medicine, FRG.
J Am Acad Dermatol. 1991 May;24(5 Pt 2):848-50. doi: 10.1016/0190-9622(91)70130-t.
Follicular mucinosis is a primary idiopathic disease or a secondary, lymphoma-associated dermatosis. An effective standard therapy for the benign group is unknown. We describe a patient with primary benign disseminated progressive follicular mucinosis who was successfully treated with recombinant interferon alfa-2b and interferon-gamma. Interferons might act by down-regulation of activated inflammatory cells and/or by induction of enhanced elimination of extracellular mucin via increasing phagocytosis by macrophages.
毛囊黏蛋白病是一种原发性特发性疾病或继发性、与淋巴瘤相关的皮肤病。目前尚不存在针对良性组的有效标准治疗方法。我们描述了一名原发性良性播散性进行性毛囊黏蛋白病患者，该患者通过重组干扰素α-2b和干扰素γ成功治愈。干扰素可能通过下调活化的炎症细胞发挥作用，和/或通过增强巨噬细胞的吞噬作用诱导细胞外黏蛋白的清除增加来发挥作用。
