Ezeamuzie I C, Igbigbi P S, Ambakederemo A W, Abila B, Nwaejike I N
Department of Pharmacology, College of Medicine, University of Port Harcourt, Nigeria.
J Trop Med Hyg. 1991 Jun;94(3):184-8.
The incidence and nature of pruritus induced by chloroquine and halofantrine were studied in 82 patients with acute malaria and in 40 healthy subjects, using a visual analogue scale for quantitating pruritus. Results showed that the proportion of patients with acute malaria manifesting itch to halofantrine was significantly lower than the proportion manifesting itch to chloroquine. Furthermore, the intensity and duration of halofantrine-induced pruritus were significantly lower than those of chloroquine-induced pruritus. The few patients who itched to halofantrine all had a history of itching to chloroquine. The incidence and intensity of chloroquine-induced pruritus were significantly higher in patients with malaria than in healthy subjects. By contrast, there was no significant difference between malaria patients and healthy subjects as regards halofantrine-induced pruritus. These results suggest that itchers to halofantrine may constitute a small group within the population of itchers to chloroquine. Malaria infection appears to enhance chloroquine-induced pruritus but not halofantrine-induced pruritus and this may be of therapeutic importance.
采用视觉模拟评分法对82例急性疟疾患者和40名健康受试者进行研究，以探讨氯喹和卤泛群所致瘙痒的发生率及性质。结果显示，急性疟疾患者中出现卤泛群瘙痒的比例显著低于出现氯喹瘙痒的比例。此外，卤泛群所致瘙痒的强度和持续时间显著低于氯喹所致瘙痒。少数出现卤泛群瘙痒的患者均有氯喹瘙痒史。疟疾患者中氯喹所致瘙痒的发生率和强度显著高于健康受试者。相比之下，疟疾患者和健康受试者在卤泛群所致瘙痒方面无显著差异。这些结果表明，对卤泛群瘙痒者可能是氯喹瘙痒人群中的一小部分。疟疾感染似乎会增强氯喹所致瘙痒，但不会增强卤泛群所致瘙痒，这可能具有治疗意义。
