Jones Andrew K, Sattelle David B
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.
Invert Neurosci. 2008 Mar;8(1):41-7. doi: 10.1007/s10158-008-0068-4. Epub 2008 Feb 21.
The nematode, Caenorhabditis elegans, possesses the most extensive known superfamily of cys-loop ligand-gated ion channels (cys-loop LGICs) consisting of 102 subunit-encoding genes. Less than half of these genes have been functionally characterised which include cation-permeable channels gated by acetylcholine (ACh) and gamma-aminobutyric acid (GABA) as well as anion-selective channels gated by ACh, GABA, glutamate and serotonin. Following the guidelines set for genetic nomenclature for C. elegans, we have designated unnamed subunits as lgc genes (ligand-gated ion channels of the cys-loop superfamily). Phylogenetic analysis shows that several of these lgc subunits form distinct groups which may represent novel cys-loop LGIC subtypes.
线虫秀丽隐杆线虫拥有已知最广泛的半胱氨酸环配体门控离子通道（cys-loop LGICs）超家族，由102个亚基编码基因组成。这些基因中不到一半已得到功能表征，其中包括由乙酰胆碱（ACh）和γ-氨基丁酸（GABA）门控的阳离子通透通道，以及由ACh、GABA、谷氨酸和5-羟色胺门控的阴离子选择性通道。按照为秀丽隐杆线虫遗传命名制定的准则，我们将未命名的亚基指定为lgc基因（半胱氨酸环超家族的配体门控离子通道）。系统发育分析表明，其中几个lgc亚基形成了不同的组，可能代表新的半胱氨酸环LGIC亚型。
