Hickey Catherine, Chisholm Terry, Passmore Michael J, O'Brien Jonathon Darcy, Johnston Jennifer
Dalhousie University, Mount Hope Building, Nova Scotia Hospital, Dartmouth, NS, Canada.
Curr Alzheimer Res. 2008 Feb;5(1):52-60. doi: 10.2174/156720508783884657.
Dementia is a common, chronic and progressive illness. Many different types of dementia exist. It is important to have knowledge of the various dementia presentations so that the clinician can differentiate one type from another. Past and current approaches of classifying dementias are reviewed in this paper. The past cortical/subcortical scheme is reviewed as well as the current synucleinopathy/tauopathy scheme. This paper focuses on the most common synucleinopathies and tauopathies including Alzheimer's Dementia, Dementia with Lewy Bodies, Parkinson's Disease, Frontotemporal Dementia, Progressive Supranuclear Palsy, Multiple System Atrophy and Corticobasal Ganglionic Degeneration. We systematically approach each dementia and review cognitive, psychiatry and neurological features of each. We also compare and contrast each dementia and the synucleinopathies and taupoathies alike. Our goal is to provide the clinician with sufficient knowledge to competently and confidently diagnose a patient who presents with progressive cognitive decline and deterioration in functioning.
痴呆症是一种常见的慢性进行性疾病。存在许多不同类型的痴呆症。了解各种痴呆症的表现很重要，以便临床医生能够区分不同类型。本文回顾了过去和当前对痴呆症的分类方法。回顾了过去的皮质/皮质下分类方案以及当前的突触核蛋白病/ Tau蛋白病分类方案。本文重点关注最常见的突触核蛋白病和Tau蛋白病，包括阿尔茨海默病性痴呆、路易体痴呆、帕金森病、额颞叶痴呆、进行性核上性麻痹、多系统萎缩和皮质基底节变性。我们系统地研究每种痴呆症，并回顾其认知、精神和神经学特征。我们还对每种痴呆症以及突触核蛋白病和Tau蛋白病进行比较和对比。我们的目标是为临床医生提供足够的知识，以便能够准确、自信地诊断出出现进行性认知衰退和功能恶化的患者。
