Paraskevas Kosmas I, Mikhailidis Dimitri P, Perrea Despina
Department of Clinical Biochemistry (Vascular Disease Prevention Clinic), Royal Free Hospital and Royal Free Medical School, University College of London, Pond Street, London NW3 2QG, UK.
Curr Pharm Des. 2008;14(4):325-37.
In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons. The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.
在过去50年里，已经描述了几种腹主动脉瘤（AAA）的实验模型。这些模型帮助科学家和医生了解AAA发生和发展的病理生理机制。此外，它们还成为了开发多种用于治疗AAA的保守治疗方法（如强力霉素、马立马司他和普萘洛尔）以及手术治疗方案的手段。在过去几年中，实验模型推动了用于治疗AAA的新型血管内技术的发展。血管内移植物和经皮技术的动物模型是这些手术成功临床应用的关键步骤。此外，它们可能构成血管外科医生培训过程的一部分。本文简要介绍了不同的实验性AAA模型，并讨论了它们的临床意义。实验模型在研究领域中对于开发更成功的AAA治疗替代方案起着至关重要的作用。
