Koyama Asuka, Ito Hiroto, Nakanishi Miharu, Sawamura Kanae, Higuchi Teruhiko
National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Psychiatry Clin Neurosci. 2008 Feb;62(1):56-64. doi: 10.1111/j.1440-1819.2007.01776.x.
The objective of the present study was to identify schizophrenia inpatients who had their original regimen augmented with additional antipsychotics during acute inpatient care, and to clarify the factors associated with these additions.
The subjects were 204 schizophrenia inpatients at 34 acute care hospitals, of whom 42 (20.6%) had further antipsychotics added to their medication regimen during hospitalization.
Compared with patients who were not prescribed additional antipsychotics, the subjects were typically discharged with higher dosages of antipsychotics, principally low-potency medications. Patients who exhibited aggressive behavior, who had no physical illness, or whose psychiatrists preferred typical antipsychotics, were more likely to be prescribed additional new antipsychotics.
Alternative approaches such as intensive care for aggressive patients and educational intervention with psychiatrists may prove useful in stabilizing patients without adding new antipsychotics unless absolutely necessary, and in simplifying medication regimens.
本研究的目的是识别在急性住院治疗期间其初始治疗方案通过添加额外抗精神病药物得到强化的精神分裂症住院患者，并阐明与这些添加相关的因素。
研究对象为34家急性护理医院的204名精神分裂症住院患者，其中42名（20.6%）在住院期间其药物治疗方案中添加了额外的抗精神病药物。
与未开具额外抗精神病药物的患者相比，这些研究对象出院时通常使用更高剂量的抗精神病药物，主要是低效价药物。表现出攻击行为、没有躯体疾病或其精神科医生更喜欢使用典型抗精神病药物的患者更有可能被开具额外的新型抗精神病药物。
除非绝对必要，否则对于攻击性行为患者的重症监护以及对精神科医生的教育干预等替代方法可能有助于在不添加新抗精神病药物的情况下使患者病情稳定，并简化药物治疗方案。
