Matarese Giuseppe, De Rosa Veronica, La Cava Antonio
Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Italy.
Trends Immunol. 2008 Jan;29(1):12-7. doi: 10.1016/j.it.2007.10.006. Epub 2007 Dec 3.
The immunosuppressive properties of naturally occurring regulatory T cells (Tregs) have classically been linked to an intrinsic state of hyporesponsiveness, yet, paradoxically, Tregs are phenotypically in an activated state and have intact proliferative capacity. In consideration of several recent biochemical reports on the intracellular signaling pathways operating in activated CD4(+)CD25(+) Tregs, we argue that the responsiveness of Tregs depends greatly on the local microenvironment. In particular, what influences Tregs to remain anergic or to proliferate arises from their ability to probe the extracellular milieu to respond to external stimuli for the modulation of intracellular signaling events, leading to very different quantitative and qualitative functional outcomes.
天然存在的调节性T细胞（Tregs）的免疫抑制特性传统上与低反应性的内在状态相关联，然而，矛盾的是，Tregs在表型上处于激活状态且具有完整的增殖能力。考虑到最近关于活化的CD4(+)CD25(+) Tregs中细胞内信号通路的几份生化报告，我们认为Tregs的反应性很大程度上取决于局部微环境。特别是，影响Tregs保持无反应或增殖的因素源于它们探测细胞外环境以响应外部刺激来调节细胞内信号事件的能力，从而导致非常不同的定量和定性功能结果。
