Licinio J, Wong M L, Gold P W
Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut 06516.
Endocrinology. 1991 Jul;129(1):562-4. doi: 10.1210/endo-129-1-562.
Interleukin-1 (IL-1) is an inflammatory peptide hormone, with potent neuroendocrine effects. IL-1 stimulates the central nervous system production of corticotropin-releasing hormone (CRH), growth hormone (GH), thyroid-stimulating hormone (TSH), and somatostatin, and inhibits the secretion of prolactin and luteinizing hormone (LH). Interleukin-1 receptor antagonist (IL-1ra) is a novel cytokine, recently purified, characterized, and cloned. IL-1ra is a pure endogenous antagonist of IL-1:IL-1 function is modulated not only by local levels of IL-1, but also by the levels of IL-1ra. We have localized by in situ hybridization histochemistry IL-1ra mRNA in rat brain, in areas of importance to neuroendocrine function, such as the paraventricular nucleus (PVN) of the hypothalamus, hippocampus, as well as cerebellum. These findings indicate that IL-1ra is produced in brain in areas of relevance to the regulation of neuroendocrine function and suggest that IL-1ra may modulate the neuroendocrine effects of IL-1.
白细胞介素 -1（IL -1）是一种炎症性肽类激素，具有强大的神经内分泌效应。IL -1刺激中枢神经系统产生促肾上腺皮质激素释放激素（CRH）、生长激素（GH）、促甲状腺激素（TSH）和生长抑素，并抑制催乳素和促黄体生成素（LH）的分泌。白细胞介素 -1受体拮抗剂（IL -1ra）是一种新型细胞因子，最近已被纯化、鉴定和克隆。IL -1ra是IL -1的纯内源性拮抗剂：IL -1的功能不仅受局部IL -1水平的调节，还受IL -1ra水平的调节。我们通过原位杂交组织化学方法在大鼠脑中对神经内分泌功能重要区域，如下丘脑室旁核（PVN）、海马以及小脑中的IL -1ra mRNA进行了定位。这些发现表明IL -1ra在与神经内分泌功能调节相关的脑区产生，并提示IL -1ra可能调节IL -1的神经内分泌效应。
