Karmysheva V Ia, Gulevskaia T S, Pogodina V V
Arkh Patol. 2007 Nov-Dec;69(6):10-5.
Histological sections of the cerebellar cortex taken from 5 patients with Creutzfeldt-Jacob disease (CJD), including 3 patients with sporadic form, were comparatively studied. The rate of pathological alterations as well as localization of prion protein (PrP) deposits greatly varied in these two groups of patients. The intensity of neural loss, damage of glial cells and accumulation of PrP increased in parallel to the duration of the disease. In nvCJD, all layers of the cerebellum, the granular layer in particular, were affected to give rise to diffuse deposits of PrP and immature amyloid plaques. Vacuolization was less pronounced and occurred predominantly in the molecular layer in all patients.
对5例克雅氏病（CJD）患者（包括3例散发型患者）的小脑皮质组织切片进行了比较研究。这两组患者的病理改变率以及朊蛋白（PrP）沉积的定位差异很大。神经细胞丢失的强度、胶质细胞损伤以及PrP的积累与疾病持续时间平行增加。在变异型克雅氏病（nvCJD）中，小脑的所有层，尤其是颗粒层，均受到影响，导致PrP的弥漫性沉积和不成熟的淀粉样斑块。空泡化不太明显，且在所有患者中主要发生在分子层。
