Saravanan Sivaperuman, Azath Ismail Abulkalam, Muthusubramanian Shanmugam
Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India.
J Org Chem. 2008 Mar 21;73(6):2323-9. doi: 10.1021/jo702610j. Epub 2008 Feb 22.
A novel method for the synthesis of 1,3-enynes is described through oxidative cyclization of the semicarbazones of Michael adducts having potential nitrile functionality. Reaction of these 1,3-enynes with diaryl nitrones has yielded a diastereomeric mixture of highly substituted 2,3-dihydro-1H-pyrrole derivatives via a tandem regioselective addition with subsequent rearrangement.
描述了一种通过具有潜在腈官能团的迈克尔加成物的半缩酮的氧化环化来合成1,3-烯炔的新方法。这些1,3-烯炔与二芳基硝酮反应，通过串联区域选择性加成并随后重排，得到了高度取代的2,3-二氢-1H-吡咯衍生物的非对映体混合物。
